@article{3b70d64be2ad4eee80a53925cf82cab7,
title = "A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation",
abstract = "Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit KV4.3 leading to an increase in the transient outward potassium current (Ito) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in KV4.3 or in the auxiliary subunit K(+) Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF.",
keywords = "Adult, Age of Onset, Animals, Atrial Fibrillation, CHO Cells, Case-Control Studies, Cricetinae, Cricetulus, Denmark, Electrocardiography, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Kv Channel-Interacting Proteins, Male, Membrane Potentials, Mutation, Phenotype, Potassium, Shal Potassium Channels, Transfection, Young Adult",
author = "Olesen, {Morten Salling} and Lena Refsgaard and Holst, {Anders Gaarsdal} and Larsen, {Anders Peter} and S{\o}ren Grubb and Stig Hauns{\o} and Svendsen, {Jesper Hastrup} and Olesen, {S{\o}ren Peter} and Nicole Schmitt and Kirstine Calloe",
year = "2013",
month = jun,
day = "1",
doi = "10.1093/cvr/cvt028",
language = "English",
volume = "98",
pages = "488--95",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "3",
}