A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and (133)Xe-SPECT

Henrik W Schytz; Song Guo; Lars T Jensen; Moshe Kamar; Asaph Nini; Daryl R Gress; Messoud Ashina

doi:10.1007/s12028-012-9720-2

A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and (133)Xe-SPECT

Henrik W Schytz, Song Guo, Lars T Jensen, Moshe Kamar, Asaph Nini, Daryl R Gress, Messoud Ashina

40 Citationer (Scopus)

Abstract

There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and (133)Xenon single photon emission computer tomography ((133)Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P

Originalsprog	Engelsk
Tidsskrift	Neurocritical Care
Vol/bind	17
Udgave nummer	1
Sider (fra-til)	139-45
Antal sider	7
ISSN	1541-6933
DOI	https://doi.org/10.1007/s12028-012-9720-2
Status	Udgivet - 2012

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10.1007/s12028-012-9720-2

Citationsformater

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abstract = "There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and (133)Xenon single photon emission computer tomography ((133)Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P ",

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AU - Jensen, Lars T

AU - Kamar, Moshe

AU - Nini, Asaph

AU - Gress, Daryl R

AU - Ashina, Messoud

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A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS and (133)Xe-SPECT

Abstract

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