TY - JOUR
T1 - A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies
AU - Perani, Daniela
AU - Iaccarino, Leonardo
AU - Lammertsma, Adriaan A
AU - Windhorst, Albert D
AU - Edison, Paul
AU - Boellaard, Ronald
AU - Hansson, Oskar
AU - Nordberg, Agneta
AU - Jacobs, Andreas H
AU - IMBI Project
N1 - Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2019/8
Y1 - 2019/8
N2 - Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
AB - Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.
U2 - 10.1016/j.jalz.2019.02.004
DO - 10.1016/j.jalz.2019.02.004
M3 - Journal article
C2 - 31230910
SN - 1552-5260
VL - 15
SP - 1081
EP - 1103
JO - Alzheimer's & dementia : the journal of the Alzheimer's Association
JF - Alzheimer's & dementia : the journal of the Alzheimer's Association
IS - 8
ER -