TY - JOUR
T1 - A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage
AU - Prunell, Giselle F
AU - Mathiesen, Tiit
AU - Svendgaard, Niels-Aage
PY - 2002/12/20
Y1 - 2002/12/20
N2 - A new experimental model of subarachnoid hemorrhage (SAH) in rats is described. A needle was stereotaxically placed in the prechiasmatic cistern and 300, 250 or 200 microl of blood was injected manually, keeping the intracranial pressure (ICP) at the mean arterial blood pressure (MABP) level. An acceptable mortality was observed only after injection of 200 microl of blood. In this group, MABP and ICP increased immediately after SAH, but soon approached baseline levels. The subarachnoid blood was mainly distributed in the basal cisternal system and its estimated volume was about 95% of the amount injected. This new model resembles clinical SAH, is very reproducible, easy to use and seems to be a suitable model for studies of the pathophysiology of SAH.
AB - A new experimental model of subarachnoid hemorrhage (SAH) in rats is described. A needle was stereotaxically placed in the prechiasmatic cistern and 300, 250 or 200 microl of blood was injected manually, keeping the intracranial pressure (ICP) at the mean arterial blood pressure (MABP) level. An acceptable mortality was observed only after injection of 200 microl of blood. In this group, MABP and ICP increased immediately after SAH, but soon approached baseline levels. The subarachnoid blood was mainly distributed in the basal cisternal system and its estimated volume was about 95% of the amount injected. This new model resembles clinical SAH, is very reproducible, easy to use and seems to be a suitable model for studies of the pathophysiology of SAH.
KW - Animals
KW - Disease Models, Animal
KW - Male
KW - Rats
KW - Rats, Sprague-Dawley
KW - Subarachnoid Hemorrhage/mortality
KW - Wounds, Stab/mortality
U2 - 10.1097/00001756-200212200-00034
DO - 10.1097/00001756-200212200-00034
M3 - Journal article
C2 - 12499866
SN - 0959-4965
VL - 13
SP - 2553
EP - 2556
JO - NeuroReport
JF - NeuroReport
IS - 18
ER -