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A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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OBJECTIVE: Diagnosis and management of bipolar disorder (BD) are limited by the absence of available laboratory tests. We aimed to combine data from different molecular levels and tissues into a composite diagnostic- and state biomarker.

METHODS: Expression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT-3, IL-6 and IL-18, leukocyte counts and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid cycling patients with BD in different affective states during a 6-12-month period and in 40 age- and gender matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211samples. A composite biomarker was constructed using data driven variable selection.

RESULTS: The composite biomarker discriminated between patients with BD and healthy control individuals with an area under the receiver operating characteristic curve (AUC) of 0.81 and a sensitivity of 72% and specificity of 68% corresponding with a moderately accurate test. Discrimination between manic and depressive states had a moderate accuracy, with an AUC of 0.79 and a sensitivity of 88% and a specificity of 40%.

CONCLUSION: Combining individual biomarkers across tissues and molecular systems could be a promising avenue for research in biomarker models in BD. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind139
Udgave nummer3
Sider (fra-til)227-236
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - 1 mar. 2019

ID: 55617700