A Mouse Model that Recapitulates Cardinal Features of the 15q13.3 Microdeletion Syndrome Including Schizophrenia- and Epilepsy-Related Alterations

Kim Fejgin, Jacob Nielsen, Michelle R Birknow, Jesper F Bastlund, Vibeke Nielsen, Jes B Lauridsen, Hreinn Stefansson, Stacy Steinberg, Helge B D Sorensen, Troels E Mortensen, Peter H Larsen, Ib V Klewe, Søren V Rasmussen, Kari Stefansson, Thomas M Werge, Pekka Kallunki, Kenneth V Christensen, Michael Didriksen

86 Citationer (Scopus)

Abstract

Genome-wide scans have uncovered rare copy number variants conferring high risk of psychiatric disorders. The 15q13.3 microdeletion is associated with a considerably increased risk of idiopathic generalized epilepsy, intellectual disability, and schizophrenia.
OriginalsprogEngelsk
TidsskriftBiological Psychiatry
Vol/bind76
Udgave nummer2
Sider (fra-til)128-137
ISSN0006-3223
DOI
StatusUdgivet - 2014

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