TY - JOUR
T1 - A method to assess the default EEG macrostate and its reactivity to stimulation
AU - Serban, Cosmin-Andrei
AU - Barborica, Andrei
AU - Roceanu, Adina-Maria
AU - Mindruta, Ioana
AU - Ciurea, Jan
AU - Pâslaru, Alexandru C
AU - Zăgrean, Ana-Maria
AU - Zăgrean, Leon
AU - Moldovan, Mihai
N1 - Copyright © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
PY - 2022/2
Y1 - 2022/2
N2 - OBJECTIVE: The default mode network (DMN) is deactivated by stimulation. We aimed to assess the DMN reactivity impairment by routine EEG recordings in stroke patients with impaired consciousness.METHODS: Binocular light flashes were delivered at 1 Hz in 1-minute epochs, following a 1-minute baseline (PRE). The EEG was decomposed in a series of binary oscillatory macrostates by topographic spectral clustering. The most deactivated macrostate was labeled the default EEG macrostate (DEM). Its reactivity (DER) was quantified as the decrease in DEM occurrence probability during stimulation. A normalized DER index (DERI) was calculated as DER/PRE. The measures were compared between 14 healthy controls and 32 comatose patients under EEG monitoring following an acute stroke.RESULTS: The DEM was mapped to the posterior DMN hubs. In the patients, these DEM source dipoles were 3-4 times less frequent and were associated with an increased theta activity. Even in a reduced 6-channel montage, a DER below 6.26% corresponding to a DERI below 0.25 could discriminate the patients with sensitivity and specificity well above 80%.CONCLUSION: The method detected the DMN impairment in post-stroke coma patients.SIGNIFICANCE: The DEM and its reactivity to stimulation could be useful to monitor the DMN function at bedside.
AB - OBJECTIVE: The default mode network (DMN) is deactivated by stimulation. We aimed to assess the DMN reactivity impairment by routine EEG recordings in stroke patients with impaired consciousness.METHODS: Binocular light flashes were delivered at 1 Hz in 1-minute epochs, following a 1-minute baseline (PRE). The EEG was decomposed in a series of binary oscillatory macrostates by topographic spectral clustering. The most deactivated macrostate was labeled the default EEG macrostate (DEM). Its reactivity (DER) was quantified as the decrease in DEM occurrence probability during stimulation. A normalized DER index (DERI) was calculated as DER/PRE. The measures were compared between 14 healthy controls and 32 comatose patients under EEG monitoring following an acute stroke.RESULTS: The DEM was mapped to the posterior DMN hubs. In the patients, these DEM source dipoles were 3-4 times less frequent and were associated with an increased theta activity. Even in a reduced 6-channel montage, a DER below 6.26% corresponding to a DERI below 0.25 could discriminate the patients with sensitivity and specificity well above 80%.CONCLUSION: The method detected the DMN impairment in post-stroke coma patients.SIGNIFICANCE: The DEM and its reactivity to stimulation could be useful to monitor the DMN function at bedside.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Brain/physiopathology
KW - Brain Mapping
KW - Coma/physiopathology
KW - Default Mode Network/physiopathology
KW - Electroencephalography
KW - Humans
KW - Middle Aged
KW - Sensitivity and Specificity
KW - Young Adult
UR - http://www.scopus.com/inward/record.url?scp=85121927449&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2021.12.002
DO - 10.1016/j.clinph.2021.12.002
M3 - Journal article
C2 - 34973517
SN - 1388-2457
VL - 134
SP - 50
EP - 64
JO - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
ER -