TY - JOUR
T1 - A major role for common genetic variation in anxiety disorders
AU - Purves, Kirstin L
AU - Coleman, Jonathan R I
AU - Meier, Sandra M
AU - Rayner, Christopher
AU - Davis, Katrina A S
AU - Cheesman, Rosa
AU - Bækvad-Hansen, Marie
AU - Børglum, Anders D
AU - Wan Cho, Shing
AU - Jürgen Deckert, J
AU - Gaspar, Héléna A
AU - Bybjerg-Grauholm, Jonas
AU - Hettema, John M
AU - Hotopf, Matthew
AU - Hougaard, David
AU - Hübel, Christopher
AU - Kan, Carol
AU - McIntosh, Andrew M
AU - Mors, Ole
AU - Bo Mortensen, Preben
AU - Nordentoft, Merete
AU - Werge, Thomas
AU - Nicodemus, Kristin K
AU - Mattheisen, Manuel
AU - Breen, Gerome
AU - Eley, Thalia C
PY - 2020/12
Y1 - 2020/12
N2 - Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
AB - Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase = 25 453, ncontrol = 58 113) and an additional analysis of Current Anxiety Symptoms (ncase = 19 012, ncontrol = 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
UR - http://www.scopus.com/inward/record.url?scp=85075328965&partnerID=8YFLogxK
U2 - 10.1038/s41380-019-0559-1
DO - 10.1038/s41380-019-0559-1
M3 - Journal article
C2 - 31748690
SN - 1359-4184
VL - 25
SP - 3292
EP - 3303
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 12
ER -