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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

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Harvard

Hansen, LBS, Roager, HM, Søndertoft, NB, Gøbel, RJ, Kristensen, M, Vallès-Colomer, M, Vieira-Silva, S, Ibrügger, S, Lind, MV, Mærkedahl, RB, Bahl, MI, Madsen, ML, Havelund, J, Falony, G, Tetens, I, Nielsen, T, Allin, KH, Frandsen, HL, Hartmann, B, Holst, JJ, Sparholt, MH, Holck, J, Blennow, A, Moll, JM, Meyer, AS, Hoppe, C, Poulsen, JH, Carvalho, V, Sagnelli, D, Dalgaard, MD, Christensen, AF, Lydolph, MC, Ross, AB, Villas-Bôas, S, Brix, S, Sicheritz-Pontén, T, Buschard, K, Linneberg, A, Rumessen, JJ, Ekstrøm, CT, Ritz, C, Kristiansen, K, Nielsen, HB, Vestergaard, H, Færgeman, NJ, Raes, J, Frøkiær, H, Hansen, T, Lauritzen, L, Gupta, R, Licht, TR & Pedersen, O 2018, 'A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults' Nature Communications, bind 9, nr. 4630, s. 4630. https://doi.org/10.1038/s41467-018-07019-x

APA

Hansen, L. B. S., Roager, H. M., Søndertoft, N. B., Gøbel, R. J., Kristensen, M., Vallès-Colomer, M., ... Pedersen, O. (2018). A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. Nature Communications, 9(4630), 4630. https://doi.org/10.1038/s41467-018-07019-x

CBE

Hansen LBS, Roager HM, Søndertoft NB, Gøbel RJ, Kristensen M, Vallès-Colomer M, Vieira-Silva S, Ibrügger S, Lind MV, Mærkedahl RB, Bahl MI, Madsen ML, Havelund J, Falony G, Tetens I, Nielsen T, Allin KH, Frandsen HL, Hartmann B, Holst JJ, Sparholt MH, Holck J, Blennow A, Moll JM, Meyer AS, Hoppe C, Poulsen JH, Carvalho V, Sagnelli D, Dalgaard MD, Christensen AF, Lydolph MC, Ross AB, Villas-Bôas S, Brix S, Sicheritz-Pontén T, Buschard K, Linneberg A, Rumessen JJ, Ekstrøm CT, Ritz C, Kristiansen K, Nielsen HB, Vestergaard H, Færgeman NJ, Raes J, Frøkiær H, Hansen T, Lauritzen L, Gupta R, Licht TR, Pedersen O. 2018. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. Nature Communications. 9(4630):4630. https://doi.org/10.1038/s41467-018-07019-x

MLA

Vancouver

Hansen LBS, Roager HM, Søndertoft NB, Gøbel RJ, Kristensen M, Vallès-Colomer M o.a. A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. Nature Communications. 2018 nov 13;9(4630):4630. https://doi.org/10.1038/s41467-018-07019-x

Author

Hansen, Lea B S ; Roager, Henrik M ; Søndertoft, Nadja B ; Gøbel, Rikke J ; Kristensen, Mette ; Vallès-Colomer, Mireia ; Vieira-Silva, Sara ; Ibrügger, Sabine ; Lind, Mads V ; Mærkedahl, Rasmus B ; Bahl, Martin I ; Madsen, Mia L ; Havelund, Jesper ; Falony, Gwen ; Tetens, Inge ; Nielsen, Trine ; Allin, Kristine H ; Frandsen, Henrik L ; Hartmann, Bolette ; Holst, Jens Juul ; Sparholt, Morten H ; Holck, Jesper ; Blennow, Andreas ; Moll, Janne Marie ; Meyer, Anne S ; Hoppe, Camilla ; Poulsen, Jørgen H ; Carvalho, Vera ; Sagnelli, Domenico ; Dalgaard, Marlene D ; Christensen, Anders F ; Lydolph, Magnus Christian ; Ross, Alastair B ; Villas-Bôas, Silas ; Brix, Susanne ; Sicheritz-Pontén, Thomas ; Buschard, Karsten ; Linneberg, Allan ; Rumessen, Jüri J ; Ekstrøm, Claus T ; Ritz, Christian ; Kristiansen, Karsten ; Nielsen, H Bjørn ; Vestergaard, Henrik ; Færgeman, Nils J ; Raes, Jeroen ; Frøkiær, Hanne ; Hansen, Torben ; Lauritzen, Lotte ; Gupta, Ramneek ; Licht, Tine Rask ; Pedersen, Oluf. / A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults. I: Nature Communications. 2018 ; Bind 9, Nr. 4630. s. 4630.

Bibtex

@article{e441a9a6e7f740ec8455ca61750dc76a,
title = "A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults",
abstract = "Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.",
author = "Hansen, {Lea B S} and Roager, {Henrik M} and S{\o}ndertoft, {Nadja B} and G{\o}bel, {Rikke J} and Mette Kristensen and Mireia Vall{\`e}s-Colomer and Sara Vieira-Silva and Sabine Ibr{\"u}gger and Lind, {Mads V} and M{\ae}rkedahl, {Rasmus B} and Bahl, {Martin I} and Madsen, {Mia L} and Jesper Havelund and Gwen Falony and Inge Tetens and Trine Nielsen and Allin, {Kristine H} and Frandsen, {Henrik L} and Bolette Hartmann and Holst, {Jens Juul} and Sparholt, {Morten H} and Jesper Holck and Andreas Blennow and Moll, {Janne Marie} and Meyer, {Anne S} and Camilla Hoppe and Poulsen, {J{\o}rgen H} and Vera Carvalho and Domenico Sagnelli and Dalgaard, {Marlene D} and Christensen, {Anders F} and Lydolph, {Magnus Christian} and Ross, {Alastair B} and Silas Villas-B{\^o}as and Susanne Brix and Thomas Sicheritz-Pont{\'e}n and Karsten Buschard and Allan Linneberg and Rumessen, {J{\"u}ri J} and Ekstr{\o}m, {Claus T} and Christian Ritz and Karsten Kristiansen and Nielsen, {H Bj{\o}rn} and Henrik Vestergaard and F{\ae}rgeman, {Nils J} and Jeroen Raes and Hanne Fr{\o}ki{\ae}r and Torben Hansen and Lotte Lauritzen and Ramneek Gupta and Licht, {Tine Rask} and Oluf Pedersen",
year = "2018",
month = "11",
day = "13",
doi = "10.1038/s41467-018-07019-x",
language = "English",
volume = "9",
pages = "4630",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "4630",

}

RIS

TY - JOUR

T1 - A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

AU - Hansen, Lea B S

AU - Roager, Henrik M

AU - Søndertoft, Nadja B

AU - Gøbel, Rikke J

AU - Kristensen, Mette

AU - Vallès-Colomer, Mireia

AU - Vieira-Silva, Sara

AU - Ibrügger, Sabine

AU - Lind, Mads V

AU - Mærkedahl, Rasmus B

AU - Bahl, Martin I

AU - Madsen, Mia L

AU - Havelund, Jesper

AU - Falony, Gwen

AU - Tetens, Inge

AU - Nielsen, Trine

AU - Allin, Kristine H

AU - Frandsen, Henrik L

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Sparholt, Morten H

AU - Holck, Jesper

AU - Blennow, Andreas

AU - Moll, Janne Marie

AU - Meyer, Anne S

AU - Hoppe, Camilla

AU - Poulsen, Jørgen H

AU - Carvalho, Vera

AU - Sagnelli, Domenico

AU - Dalgaard, Marlene D

AU - Christensen, Anders F

AU - Lydolph, Magnus Christian

AU - Ross, Alastair B

AU - Villas-Bôas, Silas

AU - Brix, Susanne

AU - Sicheritz-Pontén, Thomas

AU - Buschard, Karsten

AU - Linneberg, Allan

AU - Rumessen, Jüri J

AU - Ekstrøm, Claus T

AU - Ritz, Christian

AU - Kristiansen, Karsten

AU - Nielsen, H Bjørn

AU - Vestergaard, Henrik

AU - Færgeman, Nils J

AU - Raes, Jeroen

AU - Frøkiær, Hanne

AU - Hansen, Torben

AU - Lauritzen, Lotte

AU - Gupta, Ramneek

AU - Licht, Tine Rask

AU - Pedersen, Oluf

PY - 2018/11/13

Y1 - 2018/11/13

N2 - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

AB - Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

U2 - 10.1038/s41467-018-07019-x

DO - 10.1038/s41467-018-07019-x

M3 - Journal article

VL - 9

SP - 4630

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 4630

ER -

ID: 55630181