Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Interethnic analyses of blood pressure loci in populations of East Asian and European descent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Response to: Letter to the Editor: Hemodynamic Effects of Glucagon - A literature Review

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Determinants of Fasting Hyperglucagonemia in Patients with Type 2 Diabetes and Nondiabetic Control Subjects

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Interethnic analyses of blood pressure loci in populations of East Asian and European descent

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind9
Tidsskriftsnummer4630
Sider (fra-til)4630
ISSN2041-1723
DOI
StatusUdgivet - 13 nov. 2018

ID: 55630181