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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A large-cohort, longitudinal study determines pre-cancer disease routes across different cancer types

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  1. Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma

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  2. Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

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  3. Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Balance Players of the Adaptive Immune System

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Although many diseases are associated with cancer, the full spectrum of temporal disease correlations across cancer types has not yet been characterized. A population-wide study of longitudinal disease trajectories is needed to interrogate the general medical histories of cancer patients. Here we performed a retrospective study covering a 20-year period, using 6.9 million patients from the Danish National Patient Registry linked to 0.7 million cancer patients from the Danish Cancer Registry. Statistical analysis identified all significant disease associations occurring prior to cancer diagnoses. These associations were used to build frequently occurring, longitudinal disease trajectories. Across 17 cancer types, a total of 648 significant diagnoses correlated directly with a cancer, while 168 diagnosis trajectories of time-ordered steps were identified for seven cancer types. The most common diseases across cancer types involved cardiovascular, obesity, and genitourinary diseases. A comprehensive, publicly available web tool of interactive illustrations for all cancer disease associations is provided. By exploring the pre-cancer landscape using this large dataset, we identify disease associations that can be used to derive mechanistic hypotheses for future cancer research.

OriginalsprogEngelsk
TidsskriftCancer Research
Vol/bind79
Udgave nummer4
Sider (fra-til)864-872
Antal sider9
ISSN0008-5472
DOI
StatusUdgivet - 15 feb. 2019

ID: 56392918