Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prospective frequency and motion correction for edited 1H magnetic resonance spectroscopy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A Contrast-Adaptive Method for Simultaneous Whole-Brain and Lesion Segmentation in Multiple Sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Transcranial magnetic stimulation and magnetic resonance spectroscopy: opportunities for a bimodal approach in human neuroscience

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. MR-vejledt laserablation til behandling af hjernetumorer og epilepsi

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Nondisplaceable Binding Is a Potential Confounding Factor in C-11-PBR28 Translocator Protein PET Studies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vivo techniques have been used to highlight the mechanisms of the GABA system, however, no studies have currently combined the techniques to create a high-resolution multimodal view of the GABA system. Here, we present a quantitative high-resolution in vivo atlas of the human brain benzodiazepine receptor sites (BZR) located on postsynaptic ionotropic GABAA receptors (GABAARs), generated on the basis of in vivo [11C]flumazenil Positron Emission Tomography (PET) data. Next, based on ex vivo autoradiography data, we transform the PET-generated atlas from binding values into BZR protein density. Finally, we examine the brain regional association between BZR protein density and ex vivo mRNA expression for the 19 subunits in the GABAAR, including an estimation of the minimally required expression of mRNA levels for each subunit to translate into BZR protein. This represents the first publicly available quantitative high-resolution in vivo atlas of the spatial distribution of BZR densities in the healthy human brain. The atlas provides a unique neuroscientific tool as well as novel insights into the association between mRNA expression for individual subunits in the GABAAR and the BZR density at each location in the brain.

OriginalsprogEngelsk
Artikelnummer117878
TidsskriftNeuroImage
Vol/bind232
Sider (fra-til)117878
ISSN1053-8119
DOI
StatusUdgivet - 15 maj 2021

ID: 65952189