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A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency

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Del Bel, Michael J ; Flaxman, Teresa E ; Smale, Kenneth B ; Alkjaer, Tine ; Simonsen, Erik B ; Krogsgaard, Michael R ; Benoit, Daniel L. / A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency. I: Clinical biomechanics (Bristol, Avon). 2018 ; Bind 57. s. 129-136.

Bibtex

@article{6bb05904b44b4f45a9a19f78b19921e8,
title = "A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency",
abstract = "BACKGROUND: Sex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population.METHODS: An isometric, weight-bearing, force-generation protocol required injured and healthy males and females to modulate ground reaction forces. Electromyography was used to classify the functional role of 10 lower limb muscles in their contribution to knee joint stability during various loading directions. These roles were compared between the four groups at 12 loading directions using a directional analysis.FINDINGS: Functional muscle roles were different between groups, except for injured males and healthy females. Healthy males had either joint actuators or specific joint stabilisers, but no general stabilisers; the vastus medialis and lateralis of injured males and healthy females were classified as general stabilisers while injured females added the gluteus medialis and medial gastrocnemius as general stabilisers.INTERPRETATION: A population-based hierarchy in functional muscle roles was discovered. Healthy males demonstrated the most specific muscle roles, which can be viewed as more adaptive to variable loading conditions. The more generalised stabilisation strategies seen in injured males and females would alter joint loading which may be detrimental to the knee joint health over time. In summary, (1) these injuries alter muscle roles; (2) these alterations are sex-specific; (3) rehabilitation might be optimised if sex-differences are considered.",
author = "{Del Bel}, {Michael J} and Flaxman, {Teresa E} and Smale, {Kenneth B} and Tine Alkjaer and Simonsen, {Erik B} and Krogsgaard, {Michael R} and Benoit, {Daniel L}",
note = "Copyright {\textcopyright} 2018. Published by Elsevier Ltd.",
year = "2018",
month = aug,
doi = "10.1016/j.clinbiomech.2018.06.014",
language = "English",
volume = "57",
pages = "129--136",
journal = "Clinical Biomechanics",
issn = "0268-0033",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - A hierarchy in functional muscle roles at the knee is influenced by sex and anterior cruciate ligament deficiency

AU - Del Bel, Michael J

AU - Flaxman, Teresa E

AU - Smale, Kenneth B

AU - Alkjaer, Tine

AU - Simonsen, Erik B

AU - Krogsgaard, Michael R

AU - Benoit, Daniel L

N1 - Copyright © 2018. Published by Elsevier Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - BACKGROUND: Sex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population.METHODS: An isometric, weight-bearing, force-generation protocol required injured and healthy males and females to modulate ground reaction forces. Electromyography was used to classify the functional role of 10 lower limb muscles in their contribution to knee joint stability during various loading directions. These roles were compared between the four groups at 12 loading directions using a directional analysis.FINDINGS: Functional muscle roles were different between groups, except for injured males and healthy females. Healthy males had either joint actuators or specific joint stabilisers, but no general stabilisers; the vastus medialis and lateralis of injured males and healthy females were classified as general stabilisers while injured females added the gluteus medialis and medial gastrocnemius as general stabilisers.INTERPRETATION: A population-based hierarchy in functional muscle roles was discovered. Healthy males demonstrated the most specific muscle roles, which can be viewed as more adaptive to variable loading conditions. The more generalised stabilisation strategies seen in injured males and females would alter joint loading which may be detrimental to the knee joint health over time. In summary, (1) these injuries alter muscle roles; (2) these alterations are sex-specific; (3) rehabilitation might be optimised if sex-differences are considered.

AB - BACKGROUND: Sex-related neuromuscular differences have been linked to greater risk of anterior cruciate ligament injuries in females. Despite this, it remains unclear if sex-related differences are present after injury. This study sought to determine if sex differences are present in the functional roles of knee joint muscles in an anterior cruciate ligament deficient population.METHODS: An isometric, weight-bearing, force-generation protocol required injured and healthy males and females to modulate ground reaction forces. Electromyography was used to classify the functional role of 10 lower limb muscles in their contribution to knee joint stability during various loading directions. These roles were compared between the four groups at 12 loading directions using a directional analysis.FINDINGS: Functional muscle roles were different between groups, except for injured males and healthy females. Healthy males had either joint actuators or specific joint stabilisers, but no general stabilisers; the vastus medialis and lateralis of injured males and healthy females were classified as general stabilisers while injured females added the gluteus medialis and medial gastrocnemius as general stabilisers.INTERPRETATION: A population-based hierarchy in functional muscle roles was discovered. Healthy males demonstrated the most specific muscle roles, which can be viewed as more adaptive to variable loading conditions. The more generalised stabilisation strategies seen in injured males and females would alter joint loading which may be detrimental to the knee joint health over time. In summary, (1) these injuries alter muscle roles; (2) these alterations are sex-specific; (3) rehabilitation might be optimised if sex-differences are considered.

U2 - 10.1016/j.clinbiomech.2018.06.014

DO - 10.1016/j.clinbiomech.2018.06.014

M3 - Journal article

C2 - 29986275

VL - 57

SP - 129

EP - 136

JO - Clinical Biomechanics

JF - Clinical Biomechanics

SN - 0268-0033

ER -

ID: 56199358