A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Kanta Chechi; Rima Chakaroun; Antonis Myridakis; Sofia K Forslund-Startceva; Sebastien Fromentin; Trine Nielsen; Judith Aron-Wisneswky; Eugeni Belda; Edi Prifti; Pierre Bel Lassen; Gwen Falony; Sara Vieira-Silva; Julien Chilloux; Kazuhiro Sonomura; Lesley Hoyles; Laura Martinez-Gili; Francesco Pallotti; Petros Andrikopoulos; Francesc Puig-Castellví; Romina Pacheco Tapia; Inés Castro-Dionicio; Hugo Roume; Nicolas Pons; Emmanuelle Le Chatelier; Benoit Quinquis; Nathalie Galleron; Magali Berland; Michael T Olanipekun; Manyi Jia; Angelos Manolias; Bridget Holmes; Solia Adriouch; Matthias Blüher; Luis Pedro Coelho; Kévin Da Silva; Pilar Galan; Boyang Ji; Ana Luisa Neves; Christine Rouault; Joe-Elie Salem; Valentina Tremaroli; Tue H Hansen; Nadja B Søndertoft; Christian Lewinter; Helle K Pedersen; Peter D Mark; Jens P Goetze; Lars Køber; Henrik Vestergaard; Torben Hansen; Jean-Daniel Zucker; Taka-Aki Sato; Serge Hercberg; Fredrik Bäckhed; Ivica Letunic; Jean-Michel Oppert; Jens Nielsen; Jeroen Raes; Ioanna Tzoulaki; Abbas Dehghan; Verena Zuber; Emmanuelle Bouzigon; Mark Lathrop; Parminder Raina; Philippe Froguel; Fumihiko Matsuda; Florence Demenais; Dominique Gauguier; Michael Stumvoll; Peer Bork; Oluf Pedersen; S Dusko Ehrlich; Karine Clément; Marc-Emmanuel Dumas; MetaCardis Consortium

doi:10.1038/s41467-026-69405-0

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Kanta Chechi^*, Rima Chakaroun, Antonis Myridakis, Sofia K Forslund-Startceva, Sebastien Fromentin, Trine Nielsen, Judith Aron-Wisneswky, Eugeni Belda, Edi Prifti, Pierre Bel Lassen, Gwen Falony, Sara Vieira-Silva, Julien Chilloux, Kazuhiro Sonomura, Lesley Hoyles, Laura Martinez-Gili, Francesco Pallotti, Petros Andrikopoulos, Francesc Puig-Castellví, Romina Pacheco TapiaInés Castro-Dionicio, Hugo Roume, Nicolas Pons, Emmanuelle Le Chatelier, Benoit Quinquis, Nathalie Galleron, Magali Berland, Michael T Olanipekun, Manyi Jia, Angelos Manolias, Bridget Holmes, Solia Adriouch, Matthias Blüher, Luis Pedro Coelho, Kévin Da Silva, Pilar Galan, Boyang Ji, Ana Luisa Neves, Christine Rouault, Joe-Elie Salem, Valentina Tremaroli, Tue H Hansen, Nadja B Søndertoft, Christian Lewinter, Helle K Pedersen, Peter D Mark, Jens P Goetze, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Taka-Aki Sato, Serge Hercberg, Fredrik Bäckhed, Ivica Letunic, Jean-Michel Oppert, Jens Nielsen, Jeroen Raes, Ioanna Tzoulaki, Abbas Dehghan, Verena Zuber, Emmanuelle Bouzigon, Mark Lathrop, Parminder Raina, Philippe Froguel, Fumihiko Matsuda, Florence Demenais, Dominique Gauguier, Michael Stumvoll, Peer Bork, Oluf Pedersen^*, S Dusko Ehrlich^*, Karine Clément, Marc-Emmanuel Dumas, MetaCardis Consortium

^*Corresponding author af dette arbejde

Abstract

Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.

Originalsprog	Engelsk
Artikelnummer	3477
Tidsskrift	Nature Communications
Vol/bind	17
Udgave nummer	1
ISSN	2041-1722
DOI	https://doi.org/10.1038/s41467-026-69405-0
Status	Udgivet - 5 mar. 2026

Adgang til dokumentet

10.1038/s41467-026-69405-0Licens: CC BY

Andre filer og links

Link to publication in Scopus

Citationsformater

Chechi, K., Chakaroun, R., Myridakis, A., Forslund-Startceva, S. K., Fromentin, S., Nielsen, T., Aron-Wisneswky, J., Belda, E., Prifti, E., Lassen, P. B., Falony, G., Vieira-Silva, S., Chilloux, J., Sonomura, K., Hoyles, L., Martinez-Gili, L., Pallotti, F., Andrikopoulos, P., Puig-Castellví, F., ... MetaCardis Consortium (2026). A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. Nature Communications, 17(1), Artikel 3477. https://doi.org/10.1038/s41467-026-69405-0

Chechi, K, Chakaroun, R, Myridakis, A, Forslund-Startceva, SK, Fromentin, S, Nielsen, T, Aron-Wisneswky, J, Belda, E, Prifti, E, Lassen, PB, Falony, G, Vieira-Silva, S, Chilloux, J, Sonomura, K, Hoyles, L, Martinez-Gili, L, Pallotti, F, Andrikopoulos, P, Puig-Castellví, F, Tapia, RP, Castro-Dionicio, I, Roume, H, Pons, N, Le Chatelier, E, Quinquis, B, Galleron, N, Berland, M, Olanipekun, MT, Jia, M, Manolias, A, Holmes, B, Adriouch, S, Blüher, M, Coelho, LP, Da Silva, K, Galan, P, Ji, B, Neves, AL, Rouault, C, Salem, J-E, Tremaroli, V, Hansen, TH, Søndertoft, NB, Lewinter, C, Pedersen, HK, Mark, PD , Goetze, JP , Køber, L , Vestergaard, H, Hansen, T, Zucker, J-D, Sato, T-A, Hercberg, S, Bäckhed, F, Letunic, I, Oppert, J-M, Nielsen, J, Raes, J, Tzoulaki, I, Dehghan, A, Zuber, V, Bouzigon, E, Lathrop, M, Raina, P, Froguel, P, Matsuda, F, Demenais, F, Gauguier, D, Stumvoll, M, Bork, P, Pedersen, O, Ehrlich, SD, Clément, K, Dumas, M-E & MetaCardis Consortium 2026, 'A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases', Nature Communications, bind 17, nr. 1, 3477. https://doi.org/10.1038/s41467-026-69405-0

@article{23917caaa42b4f9dab70fc44313ab306,

title = "A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases",

abstract = "Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.",

author = "Kanta Chechi and Rima Chakaroun and Antonis Myridakis and Forslund-Startceva, \{Sofia K\} and Sebastien Fromentin and Trine Nielsen and Judith Aron-Wisneswky and Eugeni Belda and Edi Prifti and Lassen, \{Pierre Bel\} and Gwen Falony and Sara Vieira-Silva and Julien Chilloux and Kazuhiro Sonomura and Lesley Hoyles and Laura Martinez-Gili and Francesco Pallotti and Petros Andrikopoulos and Francesc Puig-Castellv{\'i} and Tapia, \{Romina Pacheco\} and In{\'e}s Castro-Dionicio and Hugo Roume and Nicolas Pons and \{Le Chatelier\}, Emmanuelle and Benoit Quinquis and Nathalie Galleron and Magali Berland and Olanipekun, \{Michael T\} and Manyi Jia and Angelos Manolias and Bridget Holmes and Solia Adriouch and Matthias Bl{\"u}her and Coelho, \{Luis Pedro\} and \{Da Silva\}, K{\'e}vin and Pilar Galan and Boyang Ji and Neves, \{Ana Luisa\} and Christine Rouault and Joe-Elie Salem and Valentina Tremaroli and Hansen, \{Tue H\} and S{\o}ndertoft, \{Nadja B\} and Christian Lewinter and Pedersen, \{Helle K\} and Mark, \{Peter D\} and Goetze, \{Jens P\} and Lars K{\o}ber and Henrik Vestergaard and Torben Hansen and Jean-Daniel Zucker and Taka-Aki Sato and Serge Hercberg and Fredrik B{\"a}ckhed and Ivica Letunic and Jean-Michel Oppert and Jens Nielsen and Jeroen Raes and Ioanna Tzoulaki and Abbas Dehghan and Verena Zuber and Emmanuelle Bouzigon and Mark Lathrop and Parminder Raina and Philippe Froguel and Fumihiko Matsuda and Florence Demenais and Dominique Gauguier and Michael Stumvoll and Peer Bork and Oluf Pedersen and Ehrlich, \{S Dusko\} and Karine Cl{\'e}ment and Marc-Emmanuel Dumas and \{MetaCardis Consortium\}",

note = "{\textcopyright} 2026. The Author(s).",

year = "2026",

month = mar,

day = "5",

doi = "10.1038/s41467-026-69405-0",

language = "English",

volume = "17",

journal = "Nature Communications",

issn = "2041-1722",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

AU - Chechi, Kanta

AU - Chakaroun, Rima

AU - Myridakis, Antonis

AU - Forslund-Startceva, Sofia K

AU - Fromentin, Sebastien

AU - Nielsen, Trine

AU - Aron-Wisneswky, Judith

AU - Belda, Eugeni

AU - Prifti, Edi

AU - Lassen, Pierre Bel

AU - Falony, Gwen

AU - Vieira-Silva, Sara

AU - Chilloux, Julien

AU - Sonomura, Kazuhiro

AU - Hoyles, Lesley

AU - Martinez-Gili, Laura

AU - Pallotti, Francesco

AU - Andrikopoulos, Petros

AU - Puig-Castellví, Francesc

AU - Tapia, Romina Pacheco

AU - Castro-Dionicio, Inés

AU - Roume, Hugo

AU - Pons, Nicolas

AU - Le Chatelier, Emmanuelle

AU - Quinquis, Benoit

AU - Galleron, Nathalie

AU - Berland, Magali

AU - Olanipekun, Michael T

AU - Jia, Manyi

AU - Manolias, Angelos

AU - Holmes, Bridget

AU - Adriouch, Solia

AU - Blüher, Matthias

AU - Coelho, Luis Pedro

AU - Da Silva, Kévin

AU - Galan, Pilar

AU - Ji, Boyang

AU - Neves, Ana Luisa

AU - Rouault, Christine

AU - Salem, Joe-Elie

AU - Tremaroli, Valentina

AU - Hansen, Tue H

AU - Søndertoft, Nadja B

AU - Lewinter, Christian

AU - Pedersen, Helle K

AU - Mark, Peter D

AU - Goetze, Jens P

AU - Køber, Lars

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Zucker, Jean-Daniel

AU - Sato, Taka-Aki

AU - Hercberg, Serge

AU - Bäckhed, Fredrik

AU - Letunic, Ivica

AU - Oppert, Jean-Michel

AU - Nielsen, Jens

AU - Raes, Jeroen

AU - Tzoulaki, Ioanna

AU - Dehghan, Abbas

AU - Zuber, Verena

AU - Bouzigon, Emmanuelle

AU - Lathrop, Mark

AU - Raina, Parminder

AU - Froguel, Philippe

AU - Matsuda, Fumihiko

AU - Demenais, Florence

AU - Gauguier, Dominique

AU - Stumvoll, Michael

AU - Bork, Peer

AU - Pedersen, Oluf

AU - Ehrlich, S Dusko

AU - Clément, Karine

AU - Dumas, Marc-Emmanuel

AU - MetaCardis Consortium

PY - 2026/3/5

Y1 - 2026/3/5

N2 - Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.

AB - Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.

UR - https://www.scopus.com/pages/publications/105035873257

U2 - 10.1038/s41467-026-69405-0

DO - 10.1038/s41467-026-69405-0

M3 - Journal article

C2 - 41786749

SN - 2041-1722

VL - 17

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 3477

ER -

A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater