A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros; Thomas Folkmann Hansen; David Westergaard; Ioannis Louloudis; Sebastian Kalamajski; Timo Röder; Palle Duun Rohde; Michael Schwinn; Line Harder Clemmensen; Maria Didriksen; Mette Nyegaard; Henrik Hjalgrim; Kaspar René Nielsen; Mie Topholm Bruun; Sisse Rye Ostrowski; Christian Erikstrup; Susan Mikkelsen; Erik Sørensen; Ole Birger Vestager Pedersen; Søren Brunak; Karina Banasik; Giuseppe Nicola Giordano; DBDS Genomic Consortium; Mona Ameri  Chalmer; Maria Didriksen; Joseph Dowsett; Bjarke Feenstra; Frank Geller; Henrik Hjalgrim; Rikke Louise Jacobsen; Lisette Kogelman; Margit Anita Hørup Larsen; Christina Mikkelsen; Michael Schwinn; Lise Wegner Thørner; David Westergaard

doi:10.1038/s41598-024-51636-0

A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros, Thomas Folkmann Hansen, David Westergaard, Ioannis Louloudis, Sebastian Kalamajski, Timo Röder, Palle Duun Rohde, Michael Schwinn, Line Harder Clemmensen, Maria Didriksen, Mette Nyegaard, Henrik Hjalgrim, Kaspar René Nielsen, Mie Topholm Bruun, Sisse Rye Ostrowski, Christian Erikstrup, Susan Mikkelsen, Erik Sørensen, Ole Birger Vestager Pedersen, Søren BrunakKarina Banasik^*, Giuseppe Nicola Giordano, DBDS Genomic Consortium, Mona Ameri Chalmer (Medlem af forfattergruppering), Maria Didriksen (Medlem af forfattergruppering), Joseph Dowsett (Medlem af forfattergruppering), Bjarke Feenstra (Medlem af forfattergruppering), Frank Geller (Medlem af forfattergruppering), Henrik Hjalgrim (Medlem af forfattergruppering), Rikke Louise Jacobsen (Medlem af forfattergruppering), Lisette Kogelman (Medlem af forfattergruppering), Margit Anita Hørup Larsen (Medlem af forfattergruppering), Christina Mikkelsen (Medlem af forfattergruppering), Michael Schwinn (Medlem af forfattergruppering), Lise Wegner Thørner (Medlem af forfattergruppering), David Westergaard (Medlem af forfattergruppering)

^*Corresponding author af dette arbejde

Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

Originalsprog	Engelsk
Artikelnummer	1402
Tidsskrift	Scientific Reports
Vol/bind	14
Udgave nummer	1
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-024-51636-0
Status	Udgivet - 16 jan. 2024

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Sequeros, C. B., Hansen, T. F., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Clemmensen, L. H., Didriksen, M., Nyegaard, M., Hjalgrim, H., Nielsen, K. R., Bruun, M. T., Ostrowski, S. R., Erikstrup, C., Mikkelsen, S., Sørensen, E., Pedersen, O. B. V., ... Westergaard, D. (2024). A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports, 14(1), Artikel 1402. https://doi.org/10.1038/s41598-024-51636-0

Sequeros, CB, Hansen, TF , Westergaard, D, Louloudis, I, Kalamajski, S, Röder, T, Rohde, PD, Schwinn, M, Clemmensen, LH, Didriksen, M, Nyegaard, M, Hjalgrim, H, Nielsen, KR, Bruun, MT, Ostrowski, SR, Erikstrup, C, Mikkelsen, S, Sørensen, E, Pedersen, OBV, Brunak, S, Banasik, K, Giordano, GN, DBDS Genomic Consortium, Chalmer, MA , Didriksen, M , Dowsett, J, Feenstra, B, Geller, F , Hjalgrim, H, Jacobsen, RL, Kogelman, L, Larsen, MAH, Mikkelsen, C , Schwinn, M , Thørner, LW & Westergaard, D 2024, 'A genome-wide association study of social trust in 33,882 Danish blood donors', Scientific Reports, bind 14, nr. 1, 1402. https://doi.org/10.1038/s41598-024-51636-0

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title = "A genome-wide association study of social trust in 33,882 Danish blood donors",

abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",

author = "Sequeros, {Celia Burgos} and Hansen, {Thomas Folkmann} and David Westergaard and Ioannis Louloudis and Sebastian Kalamajski and Timo R{\"o}der and Rohde, {Palle Duun} and Michael Schwinn and Clemmensen, {Line Harder} and Maria Didriksen and Mette Nyegaard and Henrik Hjalgrim and Nielsen, {Kaspar Ren{\'e}} and Bruun, {Mie Topholm} and Ostrowski, {Sisse Rye} and Christian Erikstrup and Susan Mikkelsen and Erik S{\o}rensen and Pedersen, {Ole Birger Vestager} and S{\o}ren Brunak and Karina Banasik and Giordano, {Giuseppe Nicola} and {DBDS Genomic Consortium} and Chalmer, {Mona Ameri} and Maria Didriksen and Joseph Dowsett and Bjarke Feenstra and Frank Geller and Henrik Hjalgrim and Jacobsen, {Rikke Louise} and Lisette Kogelman and Larsen, {Margit Anita H{\o}rup} and Christina Mikkelsen and Michael Schwinn and Th{\o}rner, {Lise Wegner} and David Westergaard",

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AU - Sequeros, Celia Burgos

AU - Hansen, Thomas Folkmann

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Clemmensen, Line Harder

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - Pedersen, Ole Birger Vestager

AU - Brunak, Søren

AU - Banasik, Karina

AU - Giordano, Giuseppe Nicola

AU - DBDS Genomic Consortium

A2 - Chalmer, Mona Ameri

A2 - Didriksen, Maria

A2 - Dowsett, Joseph

A2 - Feenstra, Bjarke

A2 - Geller, Frank

A2 - Hjalgrim, Henrik

A2 - Jacobsen, Rikke Louise

A2 - Kogelman, Lisette

A2 - Larsen, Margit Anita Hørup

A2 - Mikkelsen, Christina

A2 - Schwinn, Michael

A2 - Thørner, Lise Wegner

A2 - Westergaard, David

PY - 2024/1/16

Y1 - 2024/1/16

N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

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U2 - 10.1038/s41598-024-51636-0

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M3 - Journal article

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SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

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A genome-wide association study of social trust in 33,882 Danish blood donors

Abstract

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