@article{5dc248a5c5074e45be25983969d6cbee,
title = "A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol",
abstract = "Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).",
keywords = "Adult, Aged, Aged, 80 and over, Alleles, Apolipoprotein A-II, Cholesterol, HDL, Female, GTPase-Activating Proteins, Gene-Environment Interaction, Genetic Loci, Genome-Wide Association Study, Humans, Introns, Middle Aged, Polymorphism, Single Nucleotide, Twins, Monozygotic",
author = "Ida Surakka and Whitfield, {John B} and Markus Perola and Visscher, {Peter M} and Montgomery, {Grant W} and Mario Falchi and Gonneke Willemsen and {de Geus}, {Eco J C} and Magnusson, {Patrik K E} and Kaare Christensen and S{\o}rensen, {Thorkild I A} and Pietil{\"a}inen, {Kirsi H} and Taina Rantanen and Kaisa Silander and Elisabeth Wid{\'e}n and Juha Muilu and Iffat Rahman and Ulrika Liljedahl and Ann-Christine Syv{\"a}nen and Aarno Palotie and Jaakko Kaprio and Kyvik, {Kirsten Ohm} and Pedersen, {Nancy L} and Boomsma, {Dorret I} and Tim Spector and Martin, {Nicholas G} and Samuli Ripatti and Leena Peltonen and {GenomEUtwin Project}",
year = "2012",
doi = "10.1017/thg.2012.63",
language = "English",
volume = "15",
pages = "691--9",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press Pty. Ltd",
number = "6",
}