A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol

Ida Surakka, John B Whitfield, Markus Perola, Peter M Visscher, Grant W Montgomery, Mario Falchi, Gonneke Willemsen, Eco J C de Geus, Patrik K E Magnusson, Kaare Christensen, Thorkild I A Sørensen, Kirsi H Pietiläinen, Taina Rantanen, Kaisa Silander, Elisabeth Widén, Juha Muilu, Iffat Rahman, Ulrika Liljedahl, Ann-Christine Syvänen, Aarno PalotieJaakko Kaprio, Kirsten Ohm Kyvik, Nancy L Pedersen, Dorret I Boomsma, Tim Spector, Nicholas G Martin, Samuli Ripatti, Leena Peltonen, GenomEUtwin Project

    23 Citationer (Scopus)

    Abstract

    Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).
    OriginalsprogEngelsk
    TidsskriftTwin Research and Human Genetics
    Vol/bind15
    Udgave nummer6
    Sider (fra-til)691-9
    Antal sider9
    ISSN1832-4274
    DOI
    StatusUdgivet - 2012

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