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A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS)

Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study

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  2. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ronald van Vollenhoven
  • Alexandre Voskuyl
  • George Bertsias
  • Cynthia Aranow
  • Martin Aringer
  • Laurent Arnaud
  • Anca Askanase
  • Petra Balážová
  • Eloisa Bonfa
  • Hendrika Bootsma
  • Dimitrios Boumpas
  • Ian Bruce
  • Ricard Cervera
  • Ann Clarke
  • Cindy Coney
  • Nathalie Costedoat-Chalumeau
  • László Czirják
  • Ronald Derksen
  • Andrea Doria
  • Thomas Dörner
  • Rebecca Fischer-Betz
  • Ruth Fritsch-Stork
  • Caroline Gordon
  • Winfried Graninger
  • Noémi Györi
  • Frédéric Houssiau
  • David Isenberg
  • Soren Jacobsen
  • David Jayne
  • Annegret Kuhn
  • Veronique Le Guern
  • Kirsten Lerstrøm
  • Roger Levy
  • Francinne Machado-Ribeiro
  • Xavier Mariette
  • Jamil Missaykeh
  • Eric Morand
  • Marta Mosca
  • Murat Inanc
  • Sandra Navarra
  • Irmgard Neumann
  • Marzena Olesinska
  • Michelle Petri
  • Anisur Rahman
  • Ole Petter Rekvig
  • Jozef Rovensky
  • Yehuda Shoenfeld
  • Josef Smolen
  • Angela Tincani
  • Murray Urowitz
  • Bernadette van Leeuw
  • Carlos Vasconcelos
  • Anne Voss
  • Victoria P Werth
  • Helena Zakharova
  • Asad Zoma
  • Matthias Schneider
  • Michael Ward
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OBJECTIVES: Treat-to-target recommendations have identified 'remission' as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE.

METHODS: An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%.

RESULTS: The task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by …………………. (reference to symptoms, signs, routine labs).2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician's global assessment.3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone ≤5 mg/day), maintenance immunosuppressives and/or maintenance biologics.The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life.

CONCLUSIONS: The work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.

OriginalsprogEngelsk
TidsskriftAnnals of the Rheumatic Diseases
Vol/bind76
Udgave nummer3
Sider (fra-til)554-561
Antal sider8
ISSN0003-4967
DOI
StatusUdgivet - mar. 2017

ID: 52381227