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A dual program for translation regulation in cellular proliferation and differentiation

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Harvard

Gingold, H, Tehler, D, Christoffersen, NR, Nielsen, MM, Asmar, F, Kooistra, SM, Christophersen, NS, Christensen, LL, Borre, M, Sørensen, K, Andersen, L, Andersen, C, Hulleman, E, Wurdinger, T, Ralfkiær, E, Helin, K, Grønbæk, K, Orntoft, T, Waszak, SM, Dahan, O, Pedersen, JS, Lund, AH & Pilpel, Y 2014, 'A dual program for translation regulation in cellular proliferation and differentiation' Cell, bind 158, nr. 6, s. 1281-92. https://doi.org/10.1016/j.cell.2014.08.011

APA

Gingold, H., Tehler, D., Christoffersen, N. R., Nielsen, M. M., Asmar, F., Kooistra, S. M., ... Pilpel, Y. (2014). A dual program for translation regulation in cellular proliferation and differentiation. Cell, 158(6), 1281-92. https://doi.org/10.1016/j.cell.2014.08.011

CBE

Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM, Christophersen NS, Christensen LL, Borre M, Sørensen K, Andersen L, Andersen C, Hulleman E, Wurdinger T, Ralfkiær E, Helin K, Grønbæk K, Orntoft T, Waszak SM, Dahan O, Pedersen JS, Lund AH, Pilpel Y. 2014. A dual program for translation regulation in cellular proliferation and differentiation. Cell. 158(6):1281-92. https://doi.org/10.1016/j.cell.2014.08.011

MLA

Vancouver

Gingold H, Tehler D, Christoffersen NR, Nielsen MM, Asmar F, Kooistra SM o.a. A dual program for translation regulation in cellular proliferation and differentiation. Cell. 2014 sep 11;158(6):1281-92. https://doi.org/10.1016/j.cell.2014.08.011

Author

Gingold, Hila ; Tehler, Disa ; Christoffersen, Nanna Rønbjerg ; Nielsen, Morten M ; Asmar, Fazila ; Kooistra, Susanne Marije ; Christophersen, Nicolaj Strøyer ; Christensen, Lise Lotte ; Borre, Michael ; Sørensen, Karina ; Andersen, Lars ; Andersen, Claus ; Hulleman, Esther ; Wurdinger, Tom ; Ralfkiær, Elisabeth ; Helin, Kristian ; Grønbæk, Kirsten ; Orntoft, Torben ; Waszak, Sebastian M ; Dahan, Orna ; Pedersen, Jakob Skou ; Lund, Anders H ; Pilpel, Yitzhak. / A dual program for translation regulation in cellular proliferation and differentiation. I: Cell. 2014 ; Bind 158, Nr. 6. s. 1281-92.

Bibtex

@article{fcdd08841d3f45c1b340aea18118f8e9,
title = "A dual program for translation regulation in cellular proliferation and differentiation",
abstract = "A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.",
keywords = "Anticodon, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Codon, Histones, Humans, Neoplasms, Protein Biosynthesis, RNA, Messenger, RNA, Transfer, Transcriptome",
author = "Hila Gingold and Disa Tehler and Christoffersen, {Nanna R{\o}nbjerg} and Nielsen, {Morten M} and Fazila Asmar and Kooistra, {Susanne Marije} and Christophersen, {Nicolaj Str{\o}yer} and Christensen, {Lise Lotte} and Michael Borre and Karina S{\o}rensen and Lars Andersen and Claus Andersen and Esther Hulleman and Tom Wurdinger and Elisabeth Ralfki{\ae}r and Kristian Helin and Kirsten Gr{\o}nb{\ae}k and Torben Orntoft and Waszak, {Sebastian M} and Orna Dahan and Pedersen, {Jakob Skou} and Lund, {Anders H} and Yitzhak Pilpel",
note = "Copyright {\circledC} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = "9",
day = "11",
doi = "10.1016/j.cell.2014.08.011",
language = "English",
volume = "158",
pages = "1281--92",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - A dual program for translation regulation in cellular proliferation and differentiation

AU - Gingold, Hila

AU - Tehler, Disa

AU - Christoffersen, Nanna Rønbjerg

AU - Nielsen, Morten M

AU - Asmar, Fazila

AU - Kooistra, Susanne Marije

AU - Christophersen, Nicolaj Strøyer

AU - Christensen, Lise Lotte

AU - Borre, Michael

AU - Sørensen, Karina

AU - Andersen, Lars

AU - Andersen, Claus

AU - Hulleman, Esther

AU - Wurdinger, Tom

AU - Ralfkiær, Elisabeth

AU - Helin, Kristian

AU - Grønbæk, Kirsten

AU - Orntoft, Torben

AU - Waszak, Sebastian M

AU - Dahan, Orna

AU - Pedersen, Jakob Skou

AU - Lund, Anders H

AU - Pilpel, Yitzhak

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/9/11

Y1 - 2014/9/11

N2 - A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.

AB - A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.

KW - Anticodon

KW - Cell Differentiation

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Cell Transformation, Neoplastic

KW - Codon

KW - Histones

KW - Humans

KW - Neoplasms

KW - Protein Biosynthesis

KW - RNA, Messenger

KW - RNA, Transfer

KW - Transcriptome

U2 - 10.1016/j.cell.2014.08.011

DO - 10.1016/j.cell.2014.08.011

M3 - Journal article

VL - 158

SP - 1281

EP - 1292

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -

ID: 44705250