Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A dual program for translation regulation in cellular proliferation and differentiation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Polygenic and Monogenic Basis of Blood Traits and Diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Genome-Wide Circular RNA Expression Patterns Reflect Resistance to Immunomodulatory Drugs in Multiple Myeloma Cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Protein phosphatase, Mg2+/Mn2+-dependent 1D (PPM1D) mutations in haematological cancer

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Detailed Long-Term Follow-Up of Patients Who Relapsed After the Nordic Mantle Cell Lymphoma Trials: MCL2 and MCL3

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Hila Gingold
  • Disa Tehler
  • Nanna Rønbjerg Christoffersen
  • Morten M Nielsen
  • Fazila Asmar
  • Susanne Marije Kooistra
  • Nicolaj Strøyer Christophersen
  • Lise Lotte Christensen
  • Michael Borre
  • Karina Sørensen
  • Lars Andersen
  • Claus Andersen
  • Esther Hulleman
  • Tom Wurdinger
  • Elisabeth Ralfkiær
  • Kristian Helin
  • Kirsten Grønbæk
  • Torben Orntoft
  • Sebastian M Waszak
  • Orna Dahan
  • Jakob Skou Pedersen
  • Anders H Lund
  • Yitzhak Pilpel
Vis graf over relationer

A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.

OriginalsprogEngelsk
TidsskriftCell
Vol/bind158
Udgave nummer6
Sider (fra-til)1281-92
Antal sider12
ISSN0092-8674
DOI
StatusUdgivet - 11 sep. 2014

ID: 44705250