A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

Ulrik Fahnøe, Andreas Ronit*, Ronan M G Berg, Sofie E Jørgensen, Trine H Mogensen, Alexander P Underwood, Troels K H Scheel, Jens Bukh, Ronni R Plovsing

*Corresponding author af dette arbejde

Abstract

The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19-associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (with or without DXM) and 8 non-COVID-19 critically ill controls. CARDS with DXM was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis, and FC-γ receptor signaling. Most interferon-stimulated genes were upregulated in CARDS, particularly in CARDS without DXM. In conclusion, DXM treatment was not associated with regulation of proinflammatory pathways in CARDS but with regulation of other local immune responses. Clinical Trials Registration. NCT04354584.

OriginalsprogEngelsk
Artikelnummerjiac218
TidsskriftThe Journal of infectious diseases
Vol/bind226
Udgave nummer12
Sider (fra-til)2137-2141
Antal sider5
ISSN0022-1899
DOI
StatusUdgivet - 13 dec. 2022

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