TY - JOUR
T1 - A Decade of Progress Accelerating Malaria Control in Mali
T2 - Evidence from the West Africa International Center of Excellence for Malaria Research
AU - Doumbia, Seydou
AU - Sogoba, Nafomon
AU - Diakite, Mahamadou
AU - Toure, Mahamoudou
AU - Keita, Moussa
AU - Konaté, Drissa
AU - Diawara, Sory I
AU - Diarra, Ayouba
AU - Sanogo, Daouda
AU - Kane, Fousseyni
AU - Diakite, Seidina A S
AU - Traore, Karim
AU - Thiam, Sidibé M'Baye
AU - Traoré, Sékou F
AU - Cisse, Idrissa
AU - Mihigo, Jules
AU - Coulibaly, Mamadou B
AU - Dabitao, Djeneba
AU - Alifrangis, Michael
AU - Barry, Alyssa E
AU - Müller, Günter C
AU - Beier, John C
AU - Shaffer, Jeffrey G
PY - 2022/10/11
Y1 - 2022/10/11
N2 - This article highlights over a decade of signature achievements by the West Africa International Centers for Excellence in Malaria Research (WA-ICEMR) and its partners toward guiding malaria prevention and control strategies. Since 2010, the WA-ICEMR has performed longitudinal studies to monitor and assess malaria control interventions with respect to space-time patterns, vector transmission indicators, and drug resistance markers. These activities were facilitated and supported by the Mali National Malaria Control Program. Research activities included large-scale active and passive surveillance and expanded coverage of universal long-lasting insecticide-treated bed nets and seasonal malaria chemoprevention (SMC). The findings revealed substantial declines in malaria occurrence after the scale-up of control interventions in WA-ICEMR study sites. WA-ICEMR studies showed that SMC using sulfadoxine-pyrimethamine plus amodiaquine was highly effective in preventing malaria among children under 5 years of age. An alternative SMC regimen (dihydroartemisinin plus piperaquine) was shown to be potentially more effective and provided advantages for acceptability and compliance over the standard SMC regimen. Other findings discussed in this article include higher observed multiplicity of infection rates for malaria in historically high-endemic areas, continued antimalarial drug sensitivity to Plasmodium falciparum, high outdoor malaria transmission rates, and increased insecticide resistance over the past decade. The progress achieved by the WA-ICEMR and its partners highlights the critical need for maintaining current malaria control interventions while developing novel strategies to disrupt malaria transmission. Enhanced evaluation of these strategies through research partnerships is particularly needed in the wake of reported artemisinin resistance in Southeast Asia and East Africa.
AB - This article highlights over a decade of signature achievements by the West Africa International Centers for Excellence in Malaria Research (WA-ICEMR) and its partners toward guiding malaria prevention and control strategies. Since 2010, the WA-ICEMR has performed longitudinal studies to monitor and assess malaria control interventions with respect to space-time patterns, vector transmission indicators, and drug resistance markers. These activities were facilitated and supported by the Mali National Malaria Control Program. Research activities included large-scale active and passive surveillance and expanded coverage of universal long-lasting insecticide-treated bed nets and seasonal malaria chemoprevention (SMC). The findings revealed substantial declines in malaria occurrence after the scale-up of control interventions in WA-ICEMR study sites. WA-ICEMR studies showed that SMC using sulfadoxine-pyrimethamine plus amodiaquine was highly effective in preventing malaria among children under 5 years of age. An alternative SMC regimen (dihydroartemisinin plus piperaquine) was shown to be potentially more effective and provided advantages for acceptability and compliance over the standard SMC regimen. Other findings discussed in this article include higher observed multiplicity of infection rates for malaria in historically high-endemic areas, continued antimalarial drug sensitivity to Plasmodium falciparum, high outdoor malaria transmission rates, and increased insecticide resistance over the past decade. The progress achieved by the WA-ICEMR and its partners highlights the critical need for maintaining current malaria control interventions while developing novel strategies to disrupt malaria transmission. Enhanced evaluation of these strategies through research partnerships is particularly needed in the wake of reported artemisinin resistance in Southeast Asia and East Africa.
KW - Amodiaquine/therapeutic use
KW - Antimalarials/therapeutic use
KW - Artemisinins/therapeutic use
KW - Child
KW - Child, Preschool
KW - Drug Combinations
KW - Humans
KW - Malaria/drug therapy
KW - Malaria, Falciparum/drug therapy
KW - Mali/epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85140137014&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.21-1309
DO - 10.4269/ajtmh.21-1309
M3 - Journal article
C2 - 36228923
SN - 0002-9637
VL - 107
SP - 75
EP - 83
JO - The American journal of tropical medicine and hygiene
JF - The American journal of tropical medicine and hygiene
IS - 4_Suppl
ER -