Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

A core domain set for hidradenitis suppurativa trial outcomes: an international Delphi process

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sleep disturbance in psoriasis: a case-controlled study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Short contact with nickel causes allergic contact dermatitis: an experimental study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • HIdradenitis SuppuraTiva cORe outcomes set International Collaboration (HISTORIC)
Vis graf over relationer

BACKGROUND: There is no consensus on core outcome domains for hidradenitis suppurativa (HS). Heterogeneous outcome measure instruments in clinical trials likely leads to outcome-reporting bias and limits the ability to synthesize evidence.

OBJECTIVES: To achieve global multistakeholder consensus on a core outcome set (COS) of domains regarding what to measure in clinical trials for HS.

METHODS: Six stakeholder groups participated in a Delphi process that included five anonymous e-Delphi rounds and four face-to-face consensus meetings to reach consensus on the final COS. The aim was for a 1 : 1 ratio of patients to healthcare professionals (HCPs).

RESULTS: A total of 41 patients and 52 HCPs from 19 countries in four continents participated in the consensus process, which yielded a final COS that included five domains: pain, physical signs, HS-specific quality of life, global assessment and progression of course. A sixth domain, symptoms, was highly supported by patients and not by HCPs but is recommended for the core domain set.

CONCLUSIONS: Routine adoption of the COS in future HS trials should ensure that core outcomes of importance to both patients and HCPs are collected.

OriginalsprogEngelsk
TidsskriftBritish Journal of Dermatology
Vol/bind179
Udgave nummer3
Sider (fra-til)642-650
Antal sider9
ISSN0007-0963
DOI
StatusUdgivet - sep. 2018

ID: 56061941