A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Bettina Margrethe Jensen, S Dissing, P S Skov, L K Poulsen

8 Citationer (Scopus)

Abstract

Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.
OriginalsprogEngelsk
TidsskriftInternational Archives of Allergy and Immunology
Vol/bind137
Udgave nummer2
Sider (fra-til)93-103
Antal sider11
ISSN1018-2438
DOI
StatusUdgivet - 2005

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