A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Bettina Margrethe Jensen; S Dissing; P S Skov; L K Poulsen

doi:10.1159/000085464

A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

Bettina Margrethe Jensen, S Dissing, P S Skov, L K Poulsen

Allergi, Hud- og Kønssygdomme

8 Citationer (Scopus)

Abstrakt

Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

Originalsprog	Engelsk
Tidsskrift	International Archives of Allergy and Immunology
Vol/bind	137
Udgave nummer	2
Sider (fra-til)	93-103
Antal sider	11
ISSN	1018-2438
DOI	https://doi.org/10.1159/000085464
Status	Udgivet - 2005

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10.1159/000085464

Citationsformater

@article{a0d3bbdeb33c495c832093753f705d64,

title = "A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines",

abstract = "Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.",

keywords = "Basophils, Calcium, Cell Line, Humans, Kinetics, Mast Cells, RNA, Messenger, Receptors, IgE, Up-Regulation",

author = "Jensen, {Bettina Margrethe} and S Dissing and Skov, {P S} and Poulsen, {L K}",

year = "2005",

doi = "10.1159/000085464",

language = "English",

volume = "137",

pages = "93--103",

journal = "International Archives of Allergy and Immunology",

issn = "1018-2438",

publisher = "S./Karger AG",

number = "2",

}

TY - JOUR

T1 - A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

AU - Jensen, Bettina Margrethe

AU - Dissing, S

AU - Skov, P S

AU - Poulsen, L K

PY - 2005

Y1 - 2005

N2 - Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

AB - Mast cells and basophils express the high-affinity IgE receptor FcepsilonRI. We have analysed the human mast cell line LAD2 and four subclones of the basophil cell line KU812 in order to reveal possible differences concerning the FcepsilonRI surface regulation, anti-IgE-triggered activation, FcepsilonRIalpha protein stability and the mRNA level of FcepsilonRIalpha-, beta- and the truncated beta-chain (beta(T)), and thereby determine the utility of these cell lines in investigations of the FcepsilonRI biology.

KW - Basophils

KW - Calcium

KW - Cell Line

KW - Humans

KW - Kinetics

KW - Mast Cells

KW - RNA, Messenger

KW - Receptors, IgE

KW - Up-Regulation

U2 - 10.1159/000085464

DO - 10.1159/000085464

M3 - Journal article

C2 - 15855791

VL - 137

SP - 93

EP - 103

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 2

ER -

A comparative study of the FcepsilonRI molecule on human mast cell and basophil cell lines

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