A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

A Juul; K Sørensen; L Aksglaede; I Garn; E Rajpert-De Meyts; I Hullstein; P Hemmersbach; A M Ottesen

doi:10.1210/jc.2008-1984

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

A Juul, K Sørensen, L Aksglaede, I Garn, E Rajpert-De Meyts, I Hullstein, P Hemmersbach, A M Ottesen

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27 Citationer (Scopus)

Abstrakt

Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	94
Udgave nummer	3
Sider (fra-til)	1005-11
Antal sider	7
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2008-1984
Status	Udgivet - 2009

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10.1210/jc.2008-1984

Citationsformater

Juul, A., Sørensen, K., Aksglaede, L., Garn, I., Rajpert-De Meyts, E., Hullstein, I., Hemmersbach, P., & Ottesen, A. M. (2009). A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. Journal of Clinical Endocrinology and Metabolism, 94(3), 1005-11. https://doi.org/10.1210/jc.2008-1984

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys. / Juul, A; Sørensen, K; Aksglaede, L et al.

I: Journal of Clinical Endocrinology and Metabolism, Bind 94, Nr. 3, 2009, s. 1005-11.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Juul, A, Sørensen, K, Aksglaede, L, Garn, I, Rajpert-De Meyts, E, Hullstein, I, Hemmersbach, P & Ottesen, AM 2009, 'A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys', Journal of Clinical Endocrinology and Metabolism, bind 94, nr. 3, s. 1005-11. https://doi.org/10.1210/jc.2008-1984

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title = "A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys",

abstract = "Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.",

keywords = "Adolescent, Adult, Child, Estradiol, Gene Deletion, Genotype, Glucuronosyltransferase, Humans, Male, Puberty, Testosterone",

author = "A Juul and K S{\o}rensen and L Aksglaede and I Garn and {Rajpert-De Meyts}, E and I Hullstein and P Hemmersbach and Ottesen, {A M}",

year = "2009",

doi = "10.1210/jc.2008-1984",

language = "English",

volume = "94",

pages = "1005--11",

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T1 - A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

AU - Juul, A

AU - Sørensen, K

AU - Aksglaede, L

AU - Garn, I

AU - Rajpert-De Meyts, E

AU - Hullstein, I

AU - Hemmersbach, P

AU - Ottesen, A M

PY - 2009

Y1 - 2009

N2 - Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.

AB - Testosterone (T) is excreted in urine as water-soluble glucuronidated and sulfated conjugates. The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. The aim of the study was to evaluate the influence of UGT2B17 genotypes on urinary excretion of androgen metabolites in pubertal boys.

KW - Adolescent

KW - Adult

KW - Child

KW - Estradiol

KW - Gene Deletion

KW - Genotype

KW - Glucuronosyltransferase

KW - Humans

KW - Male

KW - Puberty

KW - Testosterone

U2 - 10.1210/jc.2008-1984

DO - 10.1210/jc.2008-1984

M3 - Journal article

C2 - 19088161

VL - 94

SP - 1005

EP - 1011

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

A common deletion in the uridine diphosphate glucuronyltransferase (UGT) 2B17 gene is a strong determinant of androgen excretion in healthy pubertal boys

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