A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study.

Bidragets oversatte titel: A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study.

Jens Dilling Lundgren, Amanda Mocroft, Jose M Gatell, Bruno Ledergerber, Antonella D'Arminio Monforte, Philippe Hermans, Frank-Detlef Goebel, Anders Blaxhult, Ole Kirk, Andrew N Phillips, NN NN

    Abstract

    The risk of clinical progression for human immunodeficiency virus (HIV)-infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up were examined. Results were validated in another 2 groups of patients (n=1946 and n=1442). In total, 200 patients (9.9%) experienced clinical progression during 5177 person-years (incidence, 3.9/100 years). The most recently measured CD4 cell count, virus load, and hemoglobin level all were independently related to the risk of clinical progression, as was a diagnosis of severe AIDS before the start of HAART. On the basis of these findings, a scoring system was derived (range, 0-17). A single unit increase in the score was associated with a 38% increased risk of clinical progression (relative hazard, 1.38; 95% confidence interval, 1.33-1.43; P<.0001). The scoring system was validated with remarkably good agreement in the 2 other cohorts. This system can be used in patient and resource management.
    Bidragets oversatte titelA clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study.
    OriginalsprogEngelsk
    TidsskriftJournal of Infectious Diseases
    Vol/bind185
    Udgave nummer2
    Sider (fra-til)178-187
    Antal sider10
    ISSN0022-1899
    StatusUdgivet - 2002

    Citationsformater