A cell-autonomous signature of dysregulated protein phosphorylation underlies muscle insulin resistance in type 2 diabetes

Keyphrases

• Type 2 Diabetes Mellitus (T2DM) 100%
• Up-regulated Proteins 100%
• Muscle Insulin Resistance 100%
• Protein Phosphorylation 100%
• Non-cell Autonomous 100%
• Myoblast 60%
• Primary Defects 20%
• Type 2 Diabetic Patients 20%
• Disease Development 20%
• Human Disease 20%
• Glucose-stimulated Insulin Secretion 20%
• Diabetes Disease 20%
• Gene Transcription 20%
• Dysregulated 20%
• Cellular Mechanisms 20%
• Vesicle Trafficking 20%
• Insulin Signaling 20%
• Phosphoproteomic Analysis 20%
• Insulin Signaling Cascade 20%
• Skeletal muscle Insulin Resistance 20%
• RNA Splicing 20%
• Circulating Metabolites 20%
• Going beyond 20%
• Chromatin Remodeling 20%
• Hormone Metabolites 20%
• Mitochondrial Oxidation 20%
• Induced Pluripotent Stem Cells (iPSCs) 20%
• Tissue Crosstalk 20%
• Predicting Diseases 20%
• Rho GTPases 20%
• Early Defect 20%
• Multiple Defects 20%
• Disease-in-a-dish 20%
• Multidimensional Networks 20%

Biochemistry, Genetics and Molecular Biology

• Insulin Resistance 100%
• Insulin Signaling 100%
• Protein Phosphorylation 100%
• Glucose Transport 50%
• Genetic Transcription 50%
• Mitochondrial Respiration 50%
• Metabolite 50%
• Skeletal Muscle 50%
• Phosphoproteomics 50%
• RNA Splicing 50%
• Chromatin Remodeling 50%