TY - JOUR
T1 - A causal effects of gut microbiota in the development of migraine
AU - He, Qiang
AU - Wang, Wenjing
AU - Xiong, Yang
AU - Tao, Chuanyuan
AU - Ma, Lu
AU - Ma, Junpeng
AU - You, Chao
AU - International Headache Genetics Consortium
A2 - Chalmer, Mona Ameri
A2 - Hansen, Thomas Folkmann
A2 - Kogelman, Lisette
A2 - Olesen, Jes
N1 - © 2023. The Author(s).
PY - 2023/7/17
Y1 - 2023/7/17
N2 - BACKGROUND: The causal association between the gut microbiome and the development of migraine and its subtypes remains unclear.METHODS: The single nucleotide polymorphisms concerning gut microbiome were retrieved from the gene-wide association study (GWAS) of the MiBioGen consortium. The summary statistics datasets of migraine, migraine with aura (MA), and migraine without aura (MO) were obtained from the GWAS meta-analysis of the International Headache Genetics Consortium (IHGC) and FinnGen consortium. Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.RESULTS: In IHGC datasets, ten, five, and nine bacterial taxa were found to have a causal association with migraine, MA, and MO, respectively, (IVW, all P < 0.05). Genus.Coprococcus3 and genus.Anaerotruncus were validated in FinnGen datasets. Nine, twelve, and seven bacterial entities were identified for migraine, MA, and MO, respectively. The causal association still exists in family.Bifidobacteriaceae and order.Bifidobacteriales for migraine and MO after FDR correction. The heterogeneity and pleiotropy analyses confirmed the robustness of IVW results.CONCLUSION: Our study demonstrates that gut microbiomes may exert causal effects on migraine, MA, and MO. We provide novel evidence for the dysfunction of the gut-brain axis on migraine. Future study is required to verify the relationship between gut microbiome and the risk of migraine and its subtypes and illustrate the underlying mechanism between them.
AB - BACKGROUND: The causal association between the gut microbiome and the development of migraine and its subtypes remains unclear.METHODS: The single nucleotide polymorphisms concerning gut microbiome were retrieved from the gene-wide association study (GWAS) of the MiBioGen consortium. The summary statistics datasets of migraine, migraine with aura (MA), and migraine without aura (MO) were obtained from the GWAS meta-analysis of the International Headache Genetics Consortium (IHGC) and FinnGen consortium. Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.RESULTS: In IHGC datasets, ten, five, and nine bacterial taxa were found to have a causal association with migraine, MA, and MO, respectively, (IVW, all P < 0.05). Genus.Coprococcus3 and genus.Anaerotruncus were validated in FinnGen datasets. Nine, twelve, and seven bacterial entities were identified for migraine, MA, and MO, respectively. The causal association still exists in family.Bifidobacteriaceae and order.Bifidobacteriales for migraine and MO after FDR correction. The heterogeneity and pleiotropy analyses confirmed the robustness of IVW results.CONCLUSION: Our study demonstrates that gut microbiomes may exert causal effects on migraine, MA, and MO. We provide novel evidence for the dysfunction of the gut-brain axis on migraine. Future study is required to verify the relationship between gut microbiome and the risk of migraine and its subtypes and illustrate the underlying mechanism between them.
KW - Humans
KW - Gastrointestinal Microbiome/genetics
KW - Genetic Association Studies
KW - Genome-Wide Association Study
KW - Headache
KW - Migraine Disorders/genetics
KW - Migraine with Aura
KW - Migraine without aura
KW - Migraine
KW - Mendelian randomization
KW - Causal association
KW - Gut microbiome
KW - Migraine with aura
UR - http://www.scopus.com/inward/record.url?scp=85165058380&partnerID=8YFLogxK
U2 - 10.1186/s10194-023-01609-x
DO - 10.1186/s10194-023-01609-x
M3 - Journal article
C2 - 37460956
SN - 1129-2369
VL - 24
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 1
M1 - 90
ER -