Abstract
Introduction: The skin is a crucial barrier against external allergens and irritants. Eczema is a frequent reaction in pediatric patients with type 1 diabetes using insulin pumps and/or glucose sensors. Especially the vulnerability of the outer layer of the skin, epidermis determines the risk of eczema. Patients with for instance atopic dermatitis have been shown to have increased have been transepidermal waterloss (TEWL).
Objectives: The aim of present study is therefore to investigate the skin barrier in patients with type 1 diabetes.
Methods: This study is a case-control study of 45 patients with type 1 diabetes in different age groups (36 in the age of 4–19 years and 9 in the age of 39–75 years) compared with 45 healthy age- and sex-matched controls. For each participant TEWL, pH, sebum content and hydration have been investigated at the skin of both the volar forearm and the upper buttock besides a microbiological investigation of the skin. T-test or Kruskal -Wallis test have been used to determine a possible difference between cases and controls depending on normal or non-normal distributions.
Results: A significant difference between pH values on the forearm were found with a mean in cases of 5.4 and 5.7 in controls (p = 0.0196). No other significant differences were found between cases and controls among TEWL, sebum or hydration. The microbiological investigation found bacteria different from normal skin flora in three cases and four controls, gram-negative bacilli was found in one control and two cases.
Conclusions: These introductory data show that the overall skin barrier in patients with type 1 diabetes luckily is not very different from the skin barrier in healthy controls, but further investigations are still warranted.
Objectives: The aim of present study is therefore to investigate the skin barrier in patients with type 1 diabetes.
Methods: This study is a case-control study of 45 patients with type 1 diabetes in different age groups (36 in the age of 4–19 years and 9 in the age of 39–75 years) compared with 45 healthy age- and sex-matched controls. For each participant TEWL, pH, sebum content and hydration have been investigated at the skin of both the volar forearm and the upper buttock besides a microbiological investigation of the skin. T-test or Kruskal -Wallis test have been used to determine a possible difference between cases and controls depending on normal or non-normal distributions.
Results: A significant difference between pH values on the forearm were found with a mean in cases of 5.4 and 5.7 in controls (p = 0.0196). No other significant differences were found between cases and controls among TEWL, sebum or hydration. The microbiological investigation found bacteria different from normal skin flora in three cases and four controls, gram-negative bacilli was found in one control and two cases.
Conclusions: These introductory data show that the overall skin barrier in patients with type 1 diabetes luckily is not very different from the skin barrier in healthy controls, but further investigations are still warranted.
| Originalsprog | Engelsk |
|---|---|
| Publikationsdato | 2021 |
| Status | Udgivet - 2021 |