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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

A Biphasic Pattern of Reproductive Hormones in Healthy Female Infants -The COPENHAGEN Minipuberty Study

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DOI

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CONTEXT: Minipuberty, a period of a transient activation of the hypothalamic-pituitary-gonadal (HPG) axis in both sexes, enables evaluation of gonadal function in infants suspected of hypogonadism. However, female minipuberty remains poorly elucidated.

OBJECTIVE: We aimed to establish continuous reference ranges for the most commonly used reproductive hormones and to evaluate the dynamics of the HPG axis in females aged 0-1 year.

DESIGN: The COPENHAGEN Minipuberty Study (ClinicalTrials.gov ID: NCT02784184), a longitudinal, prospective cohort study.

SETTING: Healthy infants from Copenhagen.

PATIENTS OR OTHER PARTICIPANTS: A total of 98 healthy, term female infants followed with six examinations including venipuncture during the first year of life.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), inhibin B, anti-Müllerian hormone (AMH), estrone (E1), estradiol (E2), and sex hormone-binding globulin (SHBG) were quantified using highly sensitive methods in 266 serum samples.

RESULTS: Reference ranges were established for LH, FSH, inhibin B, AMH, E1, E2, and SHBG. Two peaks were observed in normalized mean curves for all hormones. The first peaks were timed around postnatal days 15-27 followed by a general nadir for all hormones around days 58-92. The second peaks occurred around days 107-125 for inhibin B, AMH, E1, E2, and SHBG and day 164-165 for LH and FSH.

CONCLUSIONS: We present age-related, continuous reference ranges of the most commonly used reproductive hormones and present novel data revealing a biphasic and prolonged female minipuberty.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
ISSN0021-972X
DOI
StatusE-pub ahead of print - 15 jun. 2022

Bibliografisk note

© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

ID: 78638710