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Region Hovedstaden - en del af Københavns Universitetshospital
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A bench test study of bioprosthetic valve fracture performed before versus after transcatheter valve-in-valve intervention: Insights from bench testing

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Janarthanan Sathananthan
  • Rob Fraser
  • Hoda Hatoum
  • Aaron M Barlow
  • Viktória Stanová
  • Keith B Allen
  • Adnan K Chhatriwalla
  • Régis Rieu
  • Philippe Pibarot
  • Lakshmi Prasad Dasi
  • Lars Søndergaard
  • David A Wood
  • John G Webb
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AIMS: Bioprosthetic valve fracture (BVF) may improve transvalvular gradients and transcatheter heart valve (THV) expansion during VIV interventions. However, the optimal timing of BVF is unknown. We assessed the impact of timing of BVF (before versus after) for valve-in-valve (VIV) intervention, on hydrodynamic function and THV expansion.

METHODS AND RESULTS: Three THV designs were assessed, a 23 mm SAPIEN 3 (S3), small ACURATE neo (ACn) and 23 mm Evolut R, deployed into 21 mm Mitroflow bioprosthetic surgical valves. We evaluated each THV in three groups: 1) no BVF, 2) BVF before VIV, and 3) BVF after VIV. Hydrodynamic testing was performed using a pulse duplicator to ISO 5840:2013 standard. Transvalvular gradients were lower when BVF was performed after VIV for the S3 (no BVF 15.5 mmHg, BVF before VIV 8.0 mmHg, BVF after VIV 5.6 mmHg), and the ACn (no BVF 9.8 mmHg, BVF before VIV 8.4 mmHg, BVF after VIV 5.1 mmHg). Transvalvular gradients were similar for the Evolut R, irrespective of performance of BVF or timing of BVF. BVF performed after VIV resulted in better expansion in all three THV designs. The ACn and Evolut R samples all had a mild degree of pinwheeling, and BVF timing did not impact on pinwheeling severity. The S3 samples had severe pinwheeling with no BVF, and significant improvement in pinwheeling when BVF was performed after VIV.

CONCLUSIONS: BVF performed after VIV was associated with superior THV expansion in all three THV designs tested, with lower residual transvalvular gradients in the S3 and ACn THVs. The Evolut R had similar hydrodynamic performance irrespective of BVF timing. Timing of BVF has potential implications on THV function.

OriginalsprogEngelsk
TidsskriftEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind15
Udgave nummer16
Sider (fra-til)1409-1416
Antal sider8
ISSN1774-024X
DOI
StatusUdgivet - 20 mar. 2020

ID: 59144270