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86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Improving the maturation rate of human oocytes collected ex vivo during the cryopreservation of ovarian tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

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  3. Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development

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  4. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

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  1. Expression of the Insulin-like Growth Factor System in First- and Second-Trimester Human Embryonic and Fetal Gonads

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin

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  4. Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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PURPOSE: This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported.

METHODS: PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Seven women underwent OTC prior to chemotherapy. Four of these women still had low ovarian function and had tried to conceive. They therefore had tissue autotransplanted to augment their fertility. The other three women had developed premature ovarian insufficiency (POI) after the end of treatment.

RESULTS: Worldwide, approximately 95 children have been born or will be born in the near future from OTC, including these 9 new children. Information on the perinatal outcome was found on 40 children. The mean gestational age was 39 weeks and the mean birth weight was 3168 g of the singleton pregnancies, which is within internationally recognized normal standards. Furthermore, half the singletons resulted from natural conception and all twins resulted from in vitro fertilization treatment. All seven Danish women became pregnant within 1-3 years after transplantation. They gave birth to nine healthy children.

CONCLUSION: The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method. The seven Danish women reported in this study were all in their early thirties when OTC was performed. Most other reported cases were in the women's twenties. This suggests that the follicular pool in the thirties is large enough and sufficient to sustain fertility.

OriginalsprogEngelsk
TidsskriftJournal of Assisted Reproduction and Genetics
Vol/bind34
Udgave nummer3
Sider (fra-til)325-336
ISSN1058-0468
DOI
StatusUdgivet - 2017

ID: 49574474