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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

55 th EASD Annual Meeting of the European Association for the Study of Diabetes

Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

DOI

  1. Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of high glucose levels and glucose lowering on risk of ischaemic stroke: a Mendelian randomisation study and meta-analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A New Stochastic Approach for Modeling Glycemic Disturbances in Type 2 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Ceramides and phospholipids are downregulated with liraglutide treatment: results from the LiraFlame randomized controlled trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. EDUCATION PROGRAMMES FOR PERSONS WITH TYPE 1 DIABETES USING AN INSULIN PUMP: A SYSTEMATIC REVIEW

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Is reimbursement for alerts and real-time continuous glucose monitoring needed?

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer
Background and Aim: Reduction of carbohydrate intake stabilizes glucose levels in persons with type 1 diabetes (T1D). To maintain similar energy intake, a reduction in carbohydrate must be accompanied by an increase in protein and/or fat intake. However, this dietary change may affect the lipid balance and lead to an increased risk of cardiovascular events. We investigated how blood lipid levels responded to dietary changes and how these changes related to diet-induced changes in metabolic characteristics, such as body mass index (BMI), waist circumference, systolic blood pressure (SBP), glycemic variability and time spent in hypoglycemia. Materials and Methods: Ten adults with T1D (mean±SD: age 43.6±13.8 years, diabetes duration 24.5±13.4 years, BMI 24.9±2.1 kg, HbA1c 57.6±2.6 ) using insulin pumps participated in a randomized 2-period crossover study with 12-week intervention periods of Low Carbohydrate Diet ( LCD < 100 g carbohydrates/day) or High Carbohydrate Diet (HCD > 250 g carbohydrates/day) respectively, separated by a 12-week washout period. A comprehensive lipidomics analysis was done for fasting plasma samples obtained after each diet, and changes in lipid levels were compared with paired tests. Results: In total, 245 lipid levels were identified from 9 major lipid classes (Triacylglycerides, Phosphatidylcholines, Phosphatidylethanolamines, Hexosyl Ceramide, Sphingomyelins, Lysophosphatidylcholines, Ceramides, Lactosylceramide, and Lysophoshatidylethanolamine). In the high-resolution lipidomics analysis, phosphatidylcholines and sphingomyelins were elevated after LCD (not significant). A short-chain monounsaturated sphingomyelin, SM(d34:1), was elevated after LCD compared with HCD (p=0.002; see Figure). Sphingomyelins and phosphatidylcholines were inversely associated with BMI, waist circumference, SBP and glycemic variability (not significant). SM(d34:1) did not show significant association to changes in clinical measurements. Conclusion: Plasma from persons with T1D showed an increase in a monounsaturated sphingomyelin with LCD compared to HCD. Results from this randomized cross-over study warrant for more investigation on the long-term effects of diet and lipid homeostasis in T1D.
OriginalsprogEngelsk
Artikelnummer669
TidsskriftDiabetologia
Vol/bind62
Udgave nummerSuppl 1
Sider (fra-til)1-600
Antal sider600
ISSN0012-186X
DOI
StatusUdgivet - sep. 2019
Begivenhed55th EASD Annual Meeting: EASD 2019 - Barcelona, Spanien
Varighed: 17 sep. 201920 sep. 2019

Konference

Konference55th EASD Annual Meeting: EASD 2019
LandSpanien
ByBarcelona
Periode17/09/201920/09/2019

Begivenhed

55th EASD Annual Meeting: EASD 2019

17/09/201920/09/2019

Barcelona, Spanien

Begivenhed: Konference

ID: 57798947