24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study

Simone Theilade; Maria Stenkil Lajer; Tine Willum Hansen; Christel Joergensen; Frederik Persson; Gudbjörg Andrésdottir; Henrik Reinhard; Stine Elkjaer Nielsen; Peter Lacy; Bryan Williams; Peter Rossing

doi:10.1186/1475-2840-12-122

24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study

Simone Theilade, Maria Stenkil Lajer, Tine Willum Hansen, Christel Joergensen, Frederik Persson, Gudbjörg Andrésdottir, Henrik Reinhard, Stine Elkjaer Nielsen, Peter Lacy, Bryan Williams, Peter Rossing

Amager og Hvidovre Hospital

27 Citationer (Scopus)

Abstract

BACKGROUND: Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes.

METHODS: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration (< 10 years), normoalbuminuria (< 30 mg/24 h) without receiving antihypertensive treatment (SN), 211 with longstanding diabetes (≥ 10 years) and normoalbuminuria (LN), 163 with microalbuminuria (30-299 mg/24 h) (Mi) and 186 with macroalbuminuria (> 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average.

RESULTS: In C, SN, LN, Mi and Ma mean ± SD 24 h-CASP was: 114 ± 17, 115 ± 13, 121 ± 13, 119 ± 16 and 121 ± 13 mmHg (p < 0.001); and 24 h-CPP: 38 ± 8, 38 ± 7, 44 ± 10, 46 ± 11 and 46 ± 11 mmHg, (p < 0.001).Following rigorous adjustment (24 h mean arterial pressure and conventional risk factors), 24 h-CASP and 24 h-CPP increased with diabetes, albuminuria degree, previous cardiovascular disease (CVD), retinopathy and autonomic dysfunction (p ≤ 0.031).Odds ratios per 1 standard deviation increase in 24 h-CASP, 24 h-CPP and 24 h systolic blood pressure (24 h-SBP) were for CVD: 3.19 (1.68-6.05), 1.43 (1.01-2.02) and 2.39 (1.32-4.33), retinopathy: 4.41 (2.03-9.57), 1.77 (1.17-2.68) and 3.72 (1.85-7.47) and autonomic dysfunction: 3.25 (1.65-6.41), 1.64 (1.12-2.39) and 2.89 (1.54-5.42).

CONCLUSIONS: 24 h-CASP and 24 h-CPP was higher in patients vs. controls and increased with diabetic complications independently of covariates. Furthermore, 24 h-CASP was stronger associated to complications than 24 h-SBP.The prognostic significance of 24 h-CASP and 24 h-CPP needs to be determined in follow-up studies.

TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01171248.

Originalsprog	Engelsk
Tidsskrift	Cardiovascular Diabetology
Vol/bind	12
Sider (fra-til)	122
ISSN	1475-2840
DOI	https://doi.org/10.1186/1475-2840-12-122
Status	Udgivet - 27 aug. 2013

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10.1186/1475-2840-12-122

Citationsformater

Theilade, S., Lajer, M. S., Hansen, T. W., Joergensen, C., Persson, F., Andrésdottir, G., Reinhard, H., Nielsen, S. E., Lacy, P., Williams, B., & Rossing, P. (2013). 24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study. Cardiovascular Diabetology, 12, 122. https://doi.org/10.1186/1475-2840-12-122

24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study. / Theilade, Simone; Lajer, Maria Stenkil; Hansen, Tine Willum et al.
I: Cardiovascular Diabetology, Bind 12, 27.08.2013, s. 122.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Theilade, S, Lajer, MS, Hansen, TW, Joergensen, C, Persson, F , Andrésdottir, G, Reinhard, H, Nielsen, SE, Lacy, P, Williams, B & Rossing, P 2013, '24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study', Cardiovascular Diabetology, bind 12, s. 122. https://doi.org/10.1186/1475-2840-12-122

@article{f91618ec6f4d409a8707e3f99feb5c18,

title = "24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study",

abstract = "BACKGROUND: Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes.METHODS: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration (< 10 years), normoalbuminuria (< 30 mg/24 h) without receiving antihypertensive treatment (SN), 211 with longstanding diabetes (≥ 10 years) and normoalbuminuria (LN), 163 with microalbuminuria (30-299 mg/24 h) (Mi) and 186 with macroalbuminuria (> 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average.RESULTS: In C, SN, LN, Mi and Ma mean ± SD 24 h-CASP was: 114 ± 17, 115 ± 13, 121 ± 13, 119 ± 16 and 121 ± 13 mmHg (p < 0.001); and 24 h-CPP: 38 ± 8, 38 ± 7, 44 ± 10, 46 ± 11 and 46 ± 11 mmHg, (p < 0.001).Following rigorous adjustment (24 h mean arterial pressure and conventional risk factors), 24 h-CASP and 24 h-CPP increased with diabetes, albuminuria degree, previous cardiovascular disease (CVD), retinopathy and autonomic dysfunction (p ≤ 0.031).Odds ratios per 1 standard deviation increase in 24 h-CASP, 24 h-CPP and 24 h systolic blood pressure (24 h-SBP) were for CVD: 3.19 (1.68-6.05), 1.43 (1.01-2.02) and 2.39 (1.32-4.33), retinopathy: 4.41 (2.03-9.57), 1.77 (1.17-2.68) and 3.72 (1.85-7.47) and autonomic dysfunction: 3.25 (1.65-6.41), 1.64 (1.12-2.39) and 2.89 (1.54-5.42).CONCLUSIONS: 24 h-CASP and 24 h-CPP was higher in patients vs. controls and increased with diabetic complications independently of covariates. Furthermore, 24 h-CASP was stronger associated to complications than 24 h-SBP.The prognostic significance of 24 h-CASP and 24 h-CPP needs to be determined in follow-up studies.TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01171248.",

keywords = "Adult, Aged, Albuminuria, Arterial Pressure, Autonomic Nervous System, Blood Pressure Monitoring, Ambulatory, Case-Control Studies, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Diabetic Neuropathies, Diabetic Retinopathy, Female, Humans, Hypertrophy, Left Ventricular, Linear Models, Logistic Models, Male, Manometry, Middle Aged, Multivariate Analysis, Odds Ratio, Predictive Value of Tests, Prognosis, Risk Factors, Systole, Time Factors, Journal Article, Research Support, Non-U.S. Gov't",

author = "Simone Theilade and Lajer, {Maria Stenkil} and Hansen, {Tine Willum} and Christel Joergensen and Frederik Persson and Gudbj{\"o}rg Andr{\'e}sdottir and Henrik Reinhard and Nielsen, {Stine Elkjaer} and Peter Lacy and Bryan Williams and Peter Rossing",

year = "2013",

month = aug,

day = "27",

doi = "10.1186/1475-2840-12-122",

language = "English",

volume = "12",

pages = "122",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - 24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study

AU - Theilade, Simone

AU - Lajer, Maria Stenkil

AU - Hansen, Tine Willum

AU - Joergensen, Christel

AU - Persson, Frederik

AU - Andrésdottir, Gudbjörg

AU - Reinhard, Henrik

AU - Nielsen, Stine Elkjaer

AU - Lacy, Peter

AU - Williams, Bryan

AU - Rossing, Peter

PY - 2013/8/27

Y1 - 2013/8/27

N2 - BACKGROUND: Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes.METHODS: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration (< 10 years), normoalbuminuria (< 30 mg/24 h) without receiving antihypertensive treatment (SN), 211 with longstanding diabetes (≥ 10 years) and normoalbuminuria (LN), 163 with microalbuminuria (30-299 mg/24 h) (Mi) and 186 with macroalbuminuria (> 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average.RESULTS: In C, SN, LN, Mi and Ma mean ± SD 24 h-CASP was: 114 ± 17, 115 ± 13, 121 ± 13, 119 ± 16 and 121 ± 13 mmHg (p < 0.001); and 24 h-CPP: 38 ± 8, 38 ± 7, 44 ± 10, 46 ± 11 and 46 ± 11 mmHg, (p < 0.001).Following rigorous adjustment (24 h mean arterial pressure and conventional risk factors), 24 h-CASP and 24 h-CPP increased with diabetes, albuminuria degree, previous cardiovascular disease (CVD), retinopathy and autonomic dysfunction (p ≤ 0.031).Odds ratios per 1 standard deviation increase in 24 h-CASP, 24 h-CPP and 24 h systolic blood pressure (24 h-SBP) were for CVD: 3.19 (1.68-6.05), 1.43 (1.01-2.02) and 2.39 (1.32-4.33), retinopathy: 4.41 (2.03-9.57), 1.77 (1.17-2.68) and 3.72 (1.85-7.47) and autonomic dysfunction: 3.25 (1.65-6.41), 1.64 (1.12-2.39) and 2.89 (1.54-5.42).CONCLUSIONS: 24 h-CASP and 24 h-CPP was higher in patients vs. controls and increased with diabetic complications independently of covariates. Furthermore, 24 h-CASP was stronger associated to complications than 24 h-SBP.The prognostic significance of 24 h-CASP and 24 h-CPP needs to be determined in follow-up studies.TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01171248.

AB - BACKGROUND: Non-invasive measurements of 24 hour ambulatory central aortic systolic pressure (24 h-CASP) and central pulse pressure (24 h-CPP) are now feasible. We evaluate the relationship between 24 h central blood pressure and diabetes-related complications in patients with type 1 diabetes.METHODS: The study was cross-sectional, including 715 subjects: 86 controls (C), 69 patients with short diabetes duration (< 10 years), normoalbuminuria (< 30 mg/24 h) without receiving antihypertensive treatment (SN), 211 with longstanding diabetes (≥ 10 years) and normoalbuminuria (LN), 163 with microalbuminuria (30-299 mg/24 h) (Mi) and 186 with macroalbuminuria (> 300 mg/24 h) (Ma).24 h-CASP and 24 h-CPP was measured using a tonometric wrist-watch-like device (BPro, HealthStats, Singapore) and derived using N-point moving average.RESULTS: In C, SN, LN, Mi and Ma mean ± SD 24 h-CASP was: 114 ± 17, 115 ± 13, 121 ± 13, 119 ± 16 and 121 ± 13 mmHg (p < 0.001); and 24 h-CPP: 38 ± 8, 38 ± 7, 44 ± 10, 46 ± 11 and 46 ± 11 mmHg, (p < 0.001).Following rigorous adjustment (24 h mean arterial pressure and conventional risk factors), 24 h-CASP and 24 h-CPP increased with diabetes, albuminuria degree, previous cardiovascular disease (CVD), retinopathy and autonomic dysfunction (p ≤ 0.031).Odds ratios per 1 standard deviation increase in 24 h-CASP, 24 h-CPP and 24 h systolic blood pressure (24 h-SBP) were for CVD: 3.19 (1.68-6.05), 1.43 (1.01-2.02) and 2.39 (1.32-4.33), retinopathy: 4.41 (2.03-9.57), 1.77 (1.17-2.68) and 3.72 (1.85-7.47) and autonomic dysfunction: 3.25 (1.65-6.41), 1.64 (1.12-2.39) and 2.89 (1.54-5.42).CONCLUSIONS: 24 h-CASP and 24 h-CPP was higher in patients vs. controls and increased with diabetic complications independently of covariates. Furthermore, 24 h-CASP was stronger associated to complications than 24 h-SBP.The prognostic significance of 24 h-CASP and 24 h-CPP needs to be determined in follow-up studies.TRIAL REGISTRATION: ClinicalTrials.gov ID NCT01171248.

KW - Adult

KW - Aged

KW - Albuminuria

KW - Arterial Pressure

KW - Autonomic Nervous System

KW - Blood Pressure Monitoring, Ambulatory

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 1

KW - Diabetic Nephropathies

KW - Diabetic Neuropathies

KW - Diabetic Retinopathy

KW - Female

KW - Humans

KW - Hypertrophy, Left Ventricular

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Manometry

KW - Middle Aged

KW - Multivariate Analysis

KW - Odds Ratio

KW - Predictive Value of Tests

KW - Prognosis

KW - Risk Factors

KW - Systole

KW - Time Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/1475-2840-12-122

DO - 10.1186/1475-2840-12-122

M3 - Journal article

C2 - 23978271

SN - 1475-2840

VL - 12

SP - 122

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -

24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes - a cross-sectional study

Abstract

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