2021 DORIS definition of remission in SLE: final recommendations from an international task force

Ronald F van Vollenhoven; George Bertsias; Andrea Doria; David Isenberg; Eric Morand; Michelle A Petri; Bernardo A Pons-Estel; Anisur Rahman; Manuel Francisco Ugarte-Gil; Alexandre Voskuyl; Laurent Arnaud; Ian N Bruce; Ricard Cervera; Nathalie Costedoat-Chalumeau; Caroline Gordon; Frédéric A Houssiau; Marta Mosca; Matthias Schneider; Michael M Ward; Graciela Alarcon; Martin Aringer; Anka Askenase; Sang-Cheol Bae; Hendrika Bootsma; Dimitrios T Boumpas; Hermine Brunner; Ann Elaine Clarke; Cindy Coney; László Czirják; Thomas Dörner; Raquel Faria; Rebecca Fischer; Ruth Fritsch-Stork; Murat Inanc; Søren Jacobsen; David Jayne; Annegret Kuhn; Bernadette van Leeuw; Maarten Limper; Xavier Mariette; Sandra Navarra; Mandana Nikpour; Marzena Helena Olesinska; Guillermo Pons-Estel; Juanita Romero-Diaz; Blanca Rubio; Yehuda Schoenfeld; Eloisa Bonfá; Josef Smolen; Y K Onno Teng; Angela Tincani; Michel Tsang-A-Sjoe; Carlos Vasconcelos; Anne Voss; Victoria P Werth; Elena Zakharhova; Cynthia Aranow

doi:10.1136/lupus-2021-000538

2021 DORIS definition of remission in SLE: final recommendations from an international task force

Ronald F van Vollenhoven, George Bertsias, Andrea Doria, David Isenberg, Eric Morand, Michelle A Petri, Bernardo A Pons-Estel, Anisur Rahman, Manuel Francisco Ugarte-Gil, Alexandre Voskuyl, Laurent Arnaud, Ian N Bruce, Ricard Cervera, Nathalie Costedoat-Chalumeau, Caroline Gordon, Frédéric A Houssiau, Marta Mosca, Matthias Schneider, Michael M Ward, Graciela AlarconMartin Aringer, Anka Askenase, Sang-Cheol Bae, Hendrika Bootsma, Dimitrios T Boumpas, Hermine Brunner, Ann Elaine Clarke, Cindy Coney, László Czirják, Thomas Dörner, Raquel Faria, Rebecca Fischer, Ruth Fritsch-Stork, Murat Inanc, Søren Jacobsen, David Jayne, Annegret Kuhn, Bernadette van Leeuw, Maarten Limper, Xavier Mariette, Sandra Navarra, Mandana Nikpour, Marzena Helena Olesinska, Guillermo Pons-Estel, Juanita Romero-Diaz, Blanca Rubio, Yehuda Schoenfeld, Eloisa Bonfá, Josef Smolen, Y K Onno Teng, Angela Tincani, Michel Tsang-A-Sjoe, Carlos Vasconcelos, Anne Voss, Victoria P Werth, Elena Zakharhova, Cynthia Aranow

Afdeling for Rygkirurgi, Led- og Bindevævssygdomme HOC

340 Citationer (Scopus)

Abstract

OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS).

BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.

METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.

RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.

CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

Originalsprog	Engelsk
Artikelnummer	e000538
Tidsskrift	Lupus science & medicine
Vol/bind	8
Udgave nummer	1
ISSN	2053-8790
DOI	https://doi.org/10.1136/lupus-2021-000538
Status	Udgivet - nov. 2021

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van Vollenhoven, R. F., Bertsias, G., Doria, A., Isenberg, D., Morand, E., Petri, M. A., Pons-Estel, B. A., Rahman, A., Ugarte-Gil, M. F., Voskuyl, A., Arnaud, L., Bruce, I. N., Cervera, R., Costedoat-Chalumeau, N., Gordon, C., Houssiau, F. A., Mosca, M., Schneider, M., Ward, M. M., ... Aranow, C. (2021). 2021 DORIS definition of remission in SLE: final recommendations from an international task force. Lupus science & medicine, 8(1), Artikel e000538. https://doi.org/10.1136/lupus-2021-000538

van Vollenhoven, RF, Bertsias, G, Doria, A, Isenberg, D, Morand, E, Petri, MA, Pons-Estel, BA, Rahman, A, Ugarte-Gil, MF, Voskuyl, A, Arnaud, L, Bruce, IN, Cervera, R, Costedoat-Chalumeau, N, Gordon, C, Houssiau, FA, Mosca, M, Schneider, M, Ward, MM, Alarcon, G, Aringer, M, Askenase, A, Bae, S-C, Bootsma, H, Boumpas, DT, Brunner, H, Clarke, AE, Coney, C, Czirják, L, Dörner, T, Faria, R, Fischer, R, Fritsch-Stork, R, Inanc, M, Jacobsen, S, Jayne, D, Kuhn, A, van Leeuw, B, Limper, M, Mariette, X, Navarra, S, Nikpour, M, Olesinska, MH, Pons-Estel, G, Romero-Diaz, J, Rubio, B, Schoenfeld, Y, Bonfá, E, Smolen, J, Teng, YKO, Tincani, A, Tsang-A-Sjoe, M, Vasconcelos, C, Voss, A, Werth, VP, Zakharhova, E & Aranow, C 2021, '2021 DORIS definition of remission in SLE: final recommendations from an international task force', Lupus science & medicine, bind 8, nr. 1, e000538. https://doi.org/10.1136/lupus-2021-000538

@article{6c13cae424c34909891d7ae3661c3c50,

title = "2021 DORIS definition of remission in SLE: final recommendations from an international task force",

abstract = "OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS).BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.",

author = "\{van Vollenhoven\}, \{Ronald F\} and George Bertsias and Andrea Doria and David Isenberg and Eric Morand and Petri, \{Michelle A\} and Pons-Estel, \{Bernardo A\} and Anisur Rahman and Ugarte-Gil, \{Manuel Francisco\} and Alexandre Voskuyl and Laurent Arnaud and Bruce, \{Ian N\} and Ricard Cervera and Nathalie Costedoat-Chalumeau and Caroline Gordon and Houssiau, \{Fr{\'e}d{\'e}ric A\} and Marta Mosca and Matthias Schneider and Ward, \{Michael M\} and Graciela Alarcon and Martin Aringer and Anka Askenase and Sang-Cheol Bae and Hendrika Bootsma and Boumpas, \{Dimitrios T\} and Hermine Brunner and Clarke, \{Ann Elaine\} and Cindy Coney and L{\'a}szl{\'o} Czirj{\'a}k and Thomas D{\"o}rner and Raquel Faria and Rebecca Fischer and Ruth Fritsch-Stork and Murat Inanc and S{\o}ren Jacobsen and David Jayne and Annegret Kuhn and \{van Leeuw\}, Bernadette and Maarten Limper and Xavier Mariette and Sandra Navarra and Mandana Nikpour and Olesinska, \{Marzena Helena\} and Guillermo Pons-Estel and Juanita Romero-Diaz and Blanca Rubio and Yehuda Schoenfeld and Eloisa Bonf{\'a} and Josef Smolen and Teng, \{Y K Onno\} and Angela Tincani and Michel Tsang-A-Sjoe and Carlos Vasconcelos and Anne Voss and Werth, \{Victoria P\} and Elena Zakharhova and Cynthia Aranow",

note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2021",

month = nov,

doi = "10.1136/lupus-2021-000538",

language = "English",

volume = "8",

journal = "Lupus science \& medicine",

issn = "2053-8790",

publisher = "BMJ Publishing Group",

number = "1",

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TY - JOUR

T1 - 2021 DORIS definition of remission in SLE

T2 - final recommendations from an international task force

AU - van Vollenhoven, Ronald F

AU - Bertsias, George

AU - Doria, Andrea

AU - Isenberg, David

AU - Morand, Eric

AU - Petri, Michelle A

AU - Pons-Estel, Bernardo A

AU - Rahman, Anisur

AU - Ugarte-Gil, Manuel Francisco

AU - Voskuyl, Alexandre

AU - Arnaud, Laurent

AU - Bruce, Ian N

AU - Cervera, Ricard

AU - Costedoat-Chalumeau, Nathalie

AU - Gordon, Caroline

AU - Houssiau, Frédéric A

AU - Mosca, Marta

AU - Schneider, Matthias

AU - Ward, Michael M

AU - Alarcon, Graciela

AU - Aringer, Martin

AU - Askenase, Anka

AU - Bae, Sang-Cheol

AU - Bootsma, Hendrika

AU - Boumpas, Dimitrios T

AU - Brunner, Hermine

AU - Clarke, Ann Elaine

AU - Coney, Cindy

AU - Czirják, László

AU - Dörner, Thomas

AU - Faria, Raquel

AU - Fischer, Rebecca

AU - Fritsch-Stork, Ruth

AU - Inanc, Murat

AU - Jacobsen, Søren

AU - Jayne, David

AU - Kuhn, Annegret

AU - van Leeuw, Bernadette

AU - Limper, Maarten

AU - Mariette, Xavier

AU - Navarra, Sandra

AU - Nikpour, Mandana

AU - Olesinska, Marzena Helena

AU - Pons-Estel, Guillermo

AU - Romero-Diaz, Juanita

AU - Rubio, Blanca

AU - Schoenfeld, Yehuda

AU - Bonfá, Eloisa

AU - Smolen, Josef

AU - Teng, Y K Onno

AU - Tincani, Angela

AU - Tsang-A-Sjoe, Michel

AU - Vasconcelos, Carlos

AU - Voss, Anne

AU - Werth, Victoria P

AU - Zakharhova, Elena

AU - Aranow, Cynthia

PY - 2021/11

Y1 - 2021/11

N2 - OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS).BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

AB - OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS).BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.RESULTS: Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator's Global Assessment <0.5 (0-3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.CONCLUSION: The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

UR - https://www.scopus.com/pages/publications/85121234911

U2 - 10.1136/lupus-2021-000538

DO - 10.1136/lupus-2021-000538

M3 - Journal article

C2 - 34819388

SN - 2053-8790

VL - 8

JO - Lupus science & medicine

JF - Lupus science & medicine

IS - 1

M1 - e000538

ER -

2021 DORIS definition of remission in SLE: final recommendations from an international task force

Abstract

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