2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Katrine B Hansen; Mette Marie Rosenkilde; Filip K Knop; Niels Wellner; Thi Ai Diep; Jens F Rehfeld; Ulrik B Andersen; Jens Juul Holst; Elo Harald Hansen

doi:10.1210/jc.2011-0647

2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Katrine B Hansen, Mette Marie Rosenkilde, Filip K Knop, Niels Wellner, Thi Ai Diep, Jens F Rehfeld, Ulrik B Andersen, Jens Juul Holst, Elo Harald Hansen

258 Citationer (Scopus)

Abstract

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	96
Udgave nummer	9
Sider (fra-til)	E1409-17
ISSN	0021-972X
DOI	https://doi.org/10.1210/jc.2011-0647
Status	Udgivet - 2011

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title = "2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans",

abstract = "Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.",

keywords = "Adult, Blood Glucose, Cyclic AMP, Enteroendocrine Cells, Glucagon-Like Peptide 1, Glycerides, Humans, Male, Oleic Acids, Receptors, G-Protein-Coupled",

author = "Hansen, \{Katrine B\} and Rosenkilde, \{Mette Marie\} and Knop, \{Filip K\} and Niels Wellner and Diep, \{Thi Ai\} and Rehfeld, \{Jens F\} and Andersen, \{Ulrik B\} and Holst, \{Jens Juul\} and Hansen, \{Elo Harald\}",

year = "2011",

doi = "10.1210/jc.2011-0647",

language = "English",

volume = "96",

pages = "E1409--17",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

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TY - JOUR

T1 - 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

AU - Hansen, Katrine B

AU - Rosenkilde, Mette Marie

AU - Knop, Filip K

AU - Wellner, Niels

AU - Diep, Thi Ai

AU - Rehfeld, Jens F

AU - Andersen, Ulrik B

AU - Holst, Jens Juul

AU - Hansen, Elo Harald

PY - 2011

Y1 - 2011

N2 - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

AB - Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.

KW - Adult

KW - Blood Glucose

KW - Cyclic AMP

KW - Enteroendocrine Cells

KW - Glucagon-Like Peptide 1

KW - Glycerides

KW - Humans

KW - Male

KW - Oleic Acids

KW - Receptors, G-Protein-Coupled

UR - https://www.scopus.com/pages/publications/80052521074

U2 - 10.1210/jc.2011-0647

DO - 10.1210/jc.2011-0647

M3 - Journal article

C2 - 21778222

SN - 0021-972X

VL - 96

SP - E1409-17

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 9

ER -

2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

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