2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

Katrine B Hansen, Mette Marie Rosenkilde, Filip K Knop, Niels Wellner, Thi Ai Diep, Jens F Rehfeld, Ulrik B Andersen, Jens Juul Holst, Elo Harald Hansen

227 Citationer (Scopus)

Abstract

Dietary fat is thought to stimulate release of incretin hormones via activation of fatty acid receptors in the intestine. However, dietary fat (triacylglycerol) is digested to 2-monoacylglycerol and fatty acids. Activation of G protein-coupled receptor 119 (GPR119) stimulates glucagon-like peptide-1 (GLP-1) release from the intestinal L-cells. We aimed to investigate if 2-oleoyl glycerol (2OG) can activate GPR119 in vitro and stimulate GLP-1 secretion in vivo.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind96
Udgave nummer9
Sider (fra-til)E1409-17
ISSN0021-972X
DOI
StatusUdgivet - 2011

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