1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain

Petr Bednarik*, Dario Goranovic, Alena Svatkova, Fabian Niess, Lukas Hingerl, Bernhard Strasser, Dinesh K Deelchand, Benjamin Spurny-Dworak, Martin Krssak, Siegfried Trattnig, Gilbert Hangel, Thomas Scherer, Rupert Lanzenberger, Wolfgang Bogner

*Corresponding author af dette arbejde
15 Citationer (Scopus)

Abstract

Impaired glucose metabolism in the brain has been linked to several neurological disorders. Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging (MRSI) can be used to quantify the metabolism of glucose, but these methods involve exposure to radiation, cannot quantify downstream metabolism, or have poor spatial resolution. Deuterium MRSI (2H-MRSI) is a non-invasive and safe alternative for the quantification of the metabolism of 2H-labelled substrates such as glucose and their downstream metabolic products, yet it can only measure a limited number of deuterated compounds and requires specialized hardware. Here we show that proton MRSI (1H-MRSI) at 7 T has higher sensitivity, chemical specificity and spatiotemporal resolution than 2H-MRSI. We used 1H-MRSI in five volunteers to differentiate glutamate, glutamine, γ-aminobutyric acid and glucose deuterated at specific molecular positions, and to simultaneously map deuterated and non-deuterated metabolites. 1H-MRSI, which is amenable to clinically available magnetic-resonance hardware, may facilitate the study of glucose metabolism in the brain and its potential roles in neurological disorders.

OriginalsprogEngelsk
TidsskriftNature Biomedical Engineering
Vol/bind7
Udgave nummer8
Sider (fra-til)1001-1013
Antal sider13
ISSN2157-846X
DOI
StatusUdgivet - 27 apr. 2023

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