@article{9b523c14ae774ccf9831d221688b1681,
title = "[18F]FLT and [18F]FDG PET for non-invasive treatment monitoring of the nicotinamide phosphoribosyltransferase inhibitor APO866 in human xenografts",
abstract = "APO866 is a new anti-tumor compound inhibiting nicotinamide phosphoribosyltransferase (NAMPT). APO866 has an anti-tumor effect in several pre-clinical tumor models and is currently in several clinical phase II studies. 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of this study was non-invasively to study effect of APO866 treatment on [18F]FLT and 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) uptake.",
keywords = "Acrylamides, Animals, Antineoplastic Agents, Biological Transport, Cell Proliferation, Clinical Trials, Phase II as Topic, Dideoxynucleosides, Drug Monitoring, Female, Fluorine Radioisotopes, Fluorodeoxyglucose F18, Gene Expression, Humans, Ki-67 Antigen, Mice, Mice, Nude, Nicotinamide Phosphoribosyltransferase, Ovarian Neoplasms, Piperidines, Positron-Emission Tomography, Radiopharmaceuticals, Tumor Burden, Xenograft Model Antitumor Assays",
author = "Jensen, {Mette Munk} and Erichsen, {Kamille Dumong} and Johnbeck, {Camilla Bardram} and Fredrik Bj{\"o}rkling and Jacob Madsen and Michael Bzorek and Jensen, {Peter Buhl} and Liselotte H{\o}jgaard and Maxwell Sehested and Andreas Kj{\ae}r",
year = "2013",
doi = "10.1371/journal.pone.0053410",
language = "English",
volume = "8",
pages = "e53410",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",
}