@article{40f575a2a365473a885f78b4824943cb,
title = "11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements",
abstract = "Small-molecule α(7) nicotinic acetylcholine receptor (α(7)nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled α(7)nAChR PET tracer would be important for in vivo quantification of α(7)nAChR binding in humans and to measure α(7)nAChR occupancy of α(7)nAChR drug candidates. Here, we present the radiosynthesis and in vivo evaluation of (11)C-NS14492 as a selective α(7)nAChR PET radioligand.",
keywords = "Alkaloids, Animals, Azabicyclo Compounds, Azocines, Bicyclo Compounds, Heterocyclic, Brain, Chromatography, High Pressure Liquid, Dose-Response Relationship, Radiation, Female, Oxadiazoles, Positron-Emission Tomography, Quinolizines, Radiopharmaceuticals, Rats, Receptors, Nicotinic, Swine, Tissue Distribution",
author = "Anders Ettrup and Mikkelsen, {Jens D} and Szabolcs Lehel and Jacob Madsen and Nielsen, {Elsebet {\O}} and Mikael Palner and Timmermann, {Daniel B} and Dan Peters and Knudsen, {Gitte M}",
year = "2011",
doi = "10.2967/jnumed.111.088815",
language = "English",
volume = "52",
pages = "1449--56",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "9",
}