β(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

Henning Bundgaard, Chia-Chi Liu, Alvaro Garcia, Elisha J Hamilton, Yifei Huang, Karin K M Chia, Stephen N Hunyor, Gemma A Figtree, Helge Kildahl Rasmussen

    75 Citationer (Scopus)

    Abstract

    inhibition of L-type Ca(2+) current contributes to negative inotropy of β(3) adrenergic receptor (β(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the β(3) AR in heart failure.
    OriginalsprogEngelsk
    TidsskriftCirculation (Baltimore)
    Vol/bind122
    Udgave nummer25
    Sider (fra-til)2699-708
    Antal sider10
    ISSN0009-7322
    DOI
    StatusUdgivet - 2010

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