β-Thalassemia heterozygote state detrimentally affects health expectation

Luciano Graffeo; Angela Vitrano; Salvatore Scondotto; Gabriella Dardanoni; Walter Sebastiano Pollina Addario; Antonino Giambona; Massimiliano Sacco; Rosario Di Maggio; Disma Renda; Federico Taormina; Andrea Triveri; Massimo Attanasio; Christian Gluud; Aurelio Maggio

doi:10.1016/j.ejim.2018.06.009

β-Thalassemia heterozygote state detrimentally affects health expectation

Luciano Graffeo
, Angela Vitrano
, Salvatore Scondotto
, Gabriella Dardanoni
, Walter Sebastiano Pollina Addario
, Antonino Giambona
, Massimiliano Sacco
, Rosario Di Maggio
, Disma Renda
, Federico Taormina
, Andrea Triveri
, Massimo Attanasio
, Christian Gluud
, Aurelio Maggio

Copenhagen Trial Unit Rigshospitalet

10 Citationer (Scopus)

Abstract

BACKGROUND: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.

METHODS: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.

RESULTS: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).

CONCLUSION: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.

Originalsprog	Engelsk
Tidsskrift	European Journal of Internal Medicine
Vol/bind	54
Sider (fra-til)	76-80
ISSN	0953-6205
DOI	https://doi.org/10.1016/j.ejim.2018.06.009
Status	Udgivet - 2018

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10.1016/j.ejim.2018.06.009

Citationsformater

Graffeo, L., Vitrano, A., Scondotto, S., Dardanoni, G., Pollina Addario, W. S., Giambona, A., Sacco, M., Di Maggio, R., Renda, D., Taormina, F., Triveri, A., Attanasio, M., Gluud, C., & Maggio, A. (2018). β-Thalassemia heterozygote state detrimentally affects health expectation. European Journal of Internal Medicine, 54, 76-80. https://doi.org/10.1016/j.ejim.2018.06.009

@article{7ba71e99415843429e943fa5f87a478c,

title = "β-Thalassemia heterozygote state detrimentally affects health expectation",

abstract = "BACKGROUND: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.METHODS: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.RESULTS: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95\% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95\% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95\% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95\% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95\% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).CONCLUSION: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.",

author = "Luciano Graffeo and Angela Vitrano and Salvatore Scondotto and Gabriella Dardanoni and \{Pollina Addario\}, \{Walter Sebastiano\} and Antonino Giambona and Massimiliano Sacco and \{Di Maggio\}, Rosario and Disma Renda and Federico Taormina and Andrea Triveri and Massimo Attanasio and Christian Gluud and Aurelio Maggio",

year = "2018",

doi = "10.1016/j.ejim.2018.06.009",

language = "English",

volume = "54",

pages = "76--80",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - β-Thalassemia heterozygote state detrimentally affects health expectation

AU - Graffeo, Luciano

AU - Vitrano, Angela

AU - Scondotto, Salvatore

AU - Dardanoni, Gabriella

AU - Pollina Addario, Walter Sebastiano

AU - Giambona, Antonino

AU - Sacco, Massimiliano

AU - Di Maggio, Rosario

AU - Renda, Disma

AU - Taormina, Federico

AU - Triveri, Andrea

AU - Attanasio, Massimo

AU - Gluud, Christian

AU - Maggio, Aurelio

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.METHODS: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.RESULTS: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).CONCLUSION: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.

AB - BACKGROUND: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state.METHODS: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality.RESULTS: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p = .426).CONCLUSION: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.

U2 - 10.1016/j.ejim.2018.06.009

DO - 10.1016/j.ejim.2018.06.009

M3 - Review

C2 - 29934240

SN - 0953-6205

VL - 54

SP - 76

EP - 80

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

ER -

β-Thalassemia heterozygote state detrimentally affects health expectation

Abstract

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