@article{8d7e6ad6340c4efd8e12029904742c26,
title = "α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts",
abstract = "Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.",
keywords = "Aged, Airway Obstruction, Europe, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Heterozygote, Humans, Male, Middle Aged, North America, Norway, Pulmonary Disease, Chronic Obstructive, Risk Factors, alpha 1-Antitrypsin, alpha 1-Antitrypsin Deficiency",
author = "Inga-Cecilie S{\o}rheim and Per Bakke and Amund Gulsvik and Pillai, \{Sreekumar G\} and Ane Johannessen and Gaarder, \{Per I\} and Campbell, \{Edward J\} and Alvar Agust{\'i} and Calverley, \{Peter M A\} and Donner, \{Claudio F\} and Make, \{Barry J\} and Rennard, \{Stephen I\} and J{\o}rgen Vestbo and Wouters, \{Emiel F M\} and Par{\'e}, \{Peter D\} and Levy, \{Robert D\} and Coxson, \{Harvey O\} and Lomas, \{David A\} and Hersh, \{Craig P\} and Silverman, \{Edwin K\}",
year = "2010",
month = nov,
day = "1",
doi = "10.1378/chest.10-0746",
language = "English",
volume = "138",
pages = "1125--32",
journal = "Chest",
issn = "0012-3692",
publisher = "Elsevier Inc.",
number = "5",
}