α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts

Inga-Cecilie Sørheim; Per Bakke; Amund Gulsvik; Sreekumar G Pillai; Ane Johannessen; Per I Gaarder; Edward J Campbell; Alvar Agustí; Peter M A Calverley; Claudio F Donner; Barry J Make; Stephen I Rennard; Jørgen Vestbo; Emiel F M Wouters; Peter D Paré; Robert D Levy; Harvey O Coxson; David A Lomas; Craig P Hersh; Edwin K Silverman

doi:10.1378/chest.10-0746

α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts

Inga-Cecilie Sørheim, Per Bakke, Amund Gulsvik, Sreekumar G Pillai, Ane Johannessen, Per I Gaarder, Edward J Campbell, Alvar Agustí, Peter M A Calverley, Claudio F Donner, Barry J Make, Stephen I Rennard, Jørgen Vestbo, Emiel F M Wouters, Peter D Paré, Robert D Levy, Harvey O Coxson, David A Lomas, Craig P Hersh, Edwin K Silverman

65 Citationer (Scopus)

Abstract

Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.

Originalsprog	Engelsk
Tidsskrift	Chest
Vol/bind	138
Udgave nummer	5
Sider (fra-til)	1125-32
Antal sider	8
ISSN	0012-3692
DOI	https://doi.org/10.1378/chest.10-0746
Status	Udgivet - 1 nov. 2010

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10.1378/chest.10-0746

Citationsformater

Sørheim, I.-C., Bakke, P., Gulsvik, A., Pillai, S. G., Johannessen, A., Gaarder, P. I., Campbell, E. J., Agustí, A., Calverley, P. M. A., Donner, C. F., Make, B. J., Rennard, S. I., Vestbo, J., Wouters, E. F. M., Paré, P. D., Levy, R. D., Coxson, H. O., Lomas, D. A., Hersh, C. P., & Silverman, E. K. (2010). α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts. Chest, 138(5), 1125-32. https://doi.org/10.1378/chest.10-0746

Sørheim, I-C, Bakke, P, Gulsvik, A, Pillai, SG, Johannessen, A, Gaarder, PI, Campbell, EJ, Agustí, A, Calverley, PMA, Donner, CF, Make, BJ, Rennard, SI, Vestbo, J, Wouters, EFM, Paré, PD, Levy, RD, Coxson, HO, Lomas, DA, Hersh, CP & Silverman, EK 2010, 'α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts', Chest, bind 138, nr. 5, s. 1125-32. https://doi.org/10.1378/chest.10-0746

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title = "α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts",

abstract = "Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.",

keywords = "Aged, Airway Obstruction, Europe, Female, Forced Expiratory Volume, Genetic Predisposition to Disease, Heterozygote, Humans, Male, Middle Aged, North America, Norway, Pulmonary Disease, Chronic Obstructive, Risk Factors, alpha 1-Antitrypsin, alpha 1-Antitrypsin Deficiency",

author = "Inga-Cecilie S{\o}rheim and Per Bakke and Amund Gulsvik and Pillai, {Sreekumar G} and Ane Johannessen and Gaarder, {Per I} and Campbell, {Edward J} and Alvar Agust{\'i} and Calverley, {Peter M A} and Donner, {Claudio F} and Make, {Barry J} and Rennard, {Stephen I} and J{\o}rgen Vestbo and Wouters, {Emiel F M} and Par{\'e}, {Peter D} and Levy, {Robert D} and Coxson, {Harvey O} and Lomas, {David A} and Hersh, {Craig P} and Silverman, {Edwin K}",

year = "2010",

month = nov,

day = "1",

doi = "10.1378/chest.10-0746",

language = "English",

volume = "138",

pages = "1125--32",

journal = "Chest",

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publisher = "American College of Chest Physicians",

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TY - JOUR

T1 - α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts

AU - Sørheim, Inga-Cecilie

AU - Bakke, Per

AU - Gulsvik, Amund

AU - Pillai, Sreekumar G

AU - Johannessen, Ane

AU - Gaarder, Per I

AU - Campbell, Edward J

AU - Agustí, Alvar

AU - Calverley, Peter M A

AU - Donner, Claudio F

AU - Make, Barry J

AU - Rennard, Stephen I

AU - Vestbo, Jørgen

AU - Wouters, Emiel F M

AU - Paré, Peter D

AU - Levy, Robert D

AU - Coxson, Harvey O

AU - Lomas, David A

AU - Hersh, Craig P

AU - Silverman, Edwin K

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.

AB - Severe α₁-antitrypsin deficiency is a known genetic risk factor for COPD. Heterozygous (protease inhibitor [PI] MZ) individuals have moderately reduced serum levels of α₁-antitrypsin, but whether they have an increased risk of COPD is uncertain.

KW - Aged

KW - Airway Obstruction

KW - Europe

KW - Female

KW - Forced Expiratory Volume

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

KW - North America

KW - Norway

KW - Pulmonary Disease, Chronic Obstructive

KW - Risk Factors

KW - alpha 1-Antitrypsin

KW - alpha 1-Antitrypsin Deficiency

U2 - 10.1378/chest.10-0746

DO - 10.1378/chest.10-0746

M3 - Journal article

C2 - 20595457

SN - 0012-3692

VL - 138

SP - 1125

EP - 1132

JO - Chest

JF - Chest

IS - 5

ER -

α₁-Antitrypsin protease inhibitor MZ heterozygosity is associated with airflow obstruction in two large cohorts

Abstract

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