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Region Hovedstaden - en del af Københavns Universitetshospital

Structural and functional brain signatures of sex-hormone transition and implications for perinatal mental health

Projekt: Typer af projekterProjekt

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Intro:
Major depression is one of the most severe public health problems. It affects twice as many women as men, with increased risk during hormonal transition phases, e.g. across pregnancy to postpartum. How sex hormone changes may trigger depressive episodes, e.g. perinatal depression (PND) is unclear, yet estrogen sensitivity appears to play a prominent role. It remains unknown if estradiol changes across the peripartum confers to PND risk through compromised serotonin signaling in susceptible women, and if this affects hippocampal volume and functional brain connectivity.
Metoder:
We conduct a longitudinal study across pregnancy, delivery and early postpartum to evaluate the interplay between sex-hormones, serotonin, hippocampal volume, connectivity, and depression and resolve if a candidate set of biomarker gene transcripts and a postpartum brain scan equally well predict PND and serotonergic tone. In an available dataset, we will also evaluate if a pharmacologically induced biphasic estradiol fluctuation affect hippocampal volume in healthy women in a manner dependent on depressive symptoms/cognition and if this translates to women peripartum.

Resultater (forventede):
Ideally, the project will guide future targeted prevention and treatment of PND, which holds promise to protect mother and thus infant brain health, long-term.
Diskussion/Impact (forventet):
StatusIgangværende
Periode01/11/202001/11/2025

ID: 61957040