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Region Hovedstaden - en del af Københavns Universitetshospital

SOOTHe: Salivary Oxytocin in OCD Treatment – Helping families

Projekt: Typer af projekterProjekt

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Objective: To evaluate oxytocin as a biomarker of child and parent behaviors involved in the process of family accommodation within pediatric obsessive-compulsive disorder (OCD).
Study Design: We will include 128 children with OCD, 128 children with no psychiatric diagnosis and the parents of both groups. Patients will be randomized to one of two family-based therapies: 1) cognitive behavioral therapy, 2) psychoeducation with relaxation training. Saliva will be collected from patients, controls and their parents at baseline and the end of treatment. Saliva will also be collected from patients and their parents at mid-treatment and 6-month follow-up. Oxytocin concentrations will be measured using immunoassay with Enzo® (NY, USA) oxytocin kits.
Novelty: Ours is the first study to compare oxytocin levels in children with OCD and healthy controls and their parents and track oxytocin levels over a 10-month period in a sample with a wide age range (8-17 years). Our study is also unique in including fathers, who also play an important role in child development and treatment.
Impact: We will establish the first laboratory in Denmark with the expertise and equipment to perform oxytocin assays. Other Danish researchers interested in the study of oxytocin or vasopressin levels, an increasingly popular field, will be able to profit from our expertise and laboratory facilities. Due to collaboration between researchers and practitioners, the CAMHC research unit is the perfect setting for translating research into clinical practice.
Potential clinical implications: Evaluating oxytocin as a biomarker of family accommodation within OCD will increase understanding of the underlying mechanisms of the disorder and its treatment. By measuring oxytocin levels in a clinical trial, we may identify children with OCD and parents who may benefit most from a family-based psychotherapy that focuses on reducing family accommodation.


  • Sundhedsvidenskab - Anxiety Disorders, Behavioral, emotional disorders onset child/adolescence, Biomarkers, Psychotherapy, Behavior Mechanisms, Randomized Controlled Clinical Trial

ID: 61915206