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Region Hovedstaden - en del af Københavns Universitetshospital

OPUS 20: A twenty-year follow-up of 578 patients with first episode psychosis in the schizophrenia spectrum included in the OPUS I trial between 1998 to 2000

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Objectives: The Danish OPUS study is the largest randomized controlled trial testing the effect of the specialized early intervention treatment among 578 patients with first episode psychosis.
The cohort has multiple follow-up points at 1, 2, 5 and 10 years which gives a unique opportunity to find long term effects that do not manifest before middle age.
Findings from the 10-year follow-up study found that the symptomatology of the patients clustered in distinct groups and it would be essential to test the robustness of these findings over time in order to develop targeted interventions, differentiated to the needs of different patient groups.
Aims: The study aims to investigate the following four research questions:
1) To describe the long-term outcomes and trajectories within one of the world’s largest cohorts of people with schizophrenia spectrum disorders, with multiple follow-up points in relation to symptom remission, cognition, functioning and recovery, 20 years after first diagnosis.
2) To investigate the long-term use of antipsychotic medication and remission of psychotic symptoms.
3) To investigate the long-term effect of early intervention in schizophrenia spectrum disorders.
4) To broadly investigate the life of participants 20 year after their first diagnosis. Especially, the impact of parenthood as part of the recovery process when diagnosed with a schizophrenia spectrum disorder including social functioning, parenting and caregiving capacity.
Method: Trained health-care professionals blinded to the original treatment allocation will conduct the 20-year follow-up. The main assessment tools will include socio-demographic factors, symptom remission of negative and psychotic symptoms, cognition, level of functioning and recovery. Also, parenting and caregiving capacities among participants who has become parents will be investigated. Participants will be asked to fill out several questioners
regarding quality of life and self-perceived health.
Logistic regression analyses will be carried out and reported as odds ratio. Latent class growth analysis will be applied to identify distinct subgroups or trajectories for psychotic and negative symptoms.
Conclusion: A 20-year follow-up of the OPUS study will provide valuable new evidence of the course of illness and outcome of patients diagnosed with first episode psychosis in the schizophrenia spectrum.


  • Sundhedsvidenskab - Schizophrenia Spectrum and Other Psychotic Disorders, Cognition, Psychological assessment and psychometrics, Recovery, Registerbased research, Randomized Controlled Clinical Trial, Suicide, cognition, Pharmacology, Psychosocial Interventions, child and adolescent psychiatry, clinical diagnostics assessments

ID: 61702111