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Region Hovedstaden - en del af Københavns Universitetshospital

Optimizing Radiostereometric Analysis (RSA) to predict long and short term outcomes after total hip arthroplasty

Projekt: Typer af projekterProjekt

  • Nebergall, Audrey K, Harris Orthopaedic Laboratory Massachusetts General Hospital, USA (Projektleder, faglig)
  • Troelsen, Anders (Projektdeltager)
  • Malchau, Henrik, The Harris Orthopaedic Laboratory, USA (Projektdeltager)
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Radiostereometric analysis (RSA) is a highly accurate and therefore useful tool for early measurement of femoral head penetration, acetabular cup stability and femoral stem stability in total hip replacements (THR). RSA is widely accepted as the most precise method to assess migration and wear early in the postoperative period. The high sensitivity of RSA measurements makes it a reliably effective tool to predict long-term patient outcomes as indications of implant failure are not detectable until much later in the follow-up period on plain radiographs.

Failure of primary THR is most commonly due to component loosening secondary to osteolysis and chronic instability and dislocation. As RSA's ability to detect very small micromotion early in follow-up is so well documented, RSA can be applied in vitro and in vivo to monitor newer technologies. This project will utilize RSA in familiar settings in 3 studies to explore new technologies of two types of polyethylene, and a new tapered femoral stem. RSA will also be used in a new setting in 1 study, to determine if polyethylene wear measurements are feasible in a dual mobility hip system followed by a registry-based study to assess implications for this implant and reasons for revision, which will serve as the basis for future recommendations of using this system with RSA.

1). Long-term (12 year) RSA and CT evaluation of the Longevity highly cross-linked polyethylene

2). Mid-term (5 year) RSA evaluation of Vitamin E diffused highly cross-linked polyethylene wear, and stability of the Regenerex acetabular shell

3). The stability of a tapered femoral stem in THA using RSA

4). Phantom assessment of the feasibility, precision, and accuracy of RSA in dual mobility acetabular components

5). Multi-national registry based outcomes of the dual mobility acetabular system


ID: 43152204