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Region Hovedstaden - en del af Københavns Universitetshospital

Neuroimmunological investigations of individuals with depression - PhD project

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Evidence that the immune system is involved in the development of depression – a severe psychiatric disorder – is rising, but the mechanisms are not yet well-understood, and prior studies have mainly investigated immunological markers in peripheral blood. Studies are sparse on cerebrospinal fluid (CSF), even though CSF is the biological material closest to the brain assessable for investigations in living patients. More knowledge on how the immune system affects the brain and identification of biomarkers relevant to (a subgroup of) patients with depression will pave the way for more precise diagnostics and other treatment modalities than the current. Thus, CSF investigations that aim to identify inflammatory biomarkers in depression are needed, particularly when combined with analyses of blood samples, microbiota and psychopathology to obtain a detailed immunological characterization of the patients. This project aims to clarify if the immune system has an influence on the development and treatment responsiveness of depression. We aim to include 100 patients with depression and 100 age and gender matched healthy controls, collecting cerebrospinal fluid, blood and feces, thorough psychiatric interviewing and cognitive testing. The study is exploratory, and we will be correlating a broad variety of biomarkers of the immune system with psychiatric symptoms. This could contribute to a paradigmatic change and pave the way for development for more effective treatments based on biomarkers in some cases, as opposed to only being based on clinical observations.


  • Sundhedsvidenskab - Anxiety Disorders, Mood Disorders, Neurocognitive/Organic Disorders, Neurodevelopmental Disorders, Biomarkers, Cognition, Epidemiologic, Genetic Techniques, Neuroimaging, Pharmacology, Registerbased research, Meta-Analysis, Observational Study, Randomized Controlled Clinical Trial

ID: 61941417