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Region Hovedstaden - en del af Københavns Universitetshospital

Neurocognitive profiles in 7-year-old offspring of parents with schizophrenia or with bipolar disorder

Projekt: Typer af projekterProjekt

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Longitudinal high-risk studies and birth cohort studies have shown, that children at genetic high risk for developing schizophrenia and at high risk for bipolar disorder have cognitive deficits, delayed neuromotor development, emotional problems, and impaired social function during childhood compared to offspring of healthy controls.

The aim of this project is to characterize the neurocognitive profiles of children at genetic high risk for schizophrenia or bipolar disorder and compare their neurocognitive profiles with children of healthy controls. We will focus on the following neurocognitive domains: General intelligence, processing speed, memory, attention, executive functions, decision making, and risk taking.

We will establish a cohort of 440 7-year-old children with either 0, 1 or 2 parents with schizophrenia spectrum psychosis or bipolar disorder (ICD-10: F20, F22, F25, F31). Children in all three groups (HR-SZ N=220; HR-BD N=120; HC N=100) will be assessed with an array of clinical and neurocognitive measures to detect symptoms and psychiatric diagnoses and to evaluate their neurocognitive function.

7-year old children with either 1 or 2 parents with either schizofrenia og bipolar disorder.
The children and their parents will be recruited through the Danish Civil Registration System and the Danish Psychiatric Central Register

FinansieringskildeAnden offentlig støtte (Offentlig)
ForskningsprogramKøbenhavns Universitet, Aarhus Universitet, RHP
FinansieringskildePrivat fond (Privat)


  • Sundhedsvidenskab - Behavioral, emotional disorders onset child/adolescence, Cognition, Observational study

ID: 36762050