Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Longitudinel undersøgelse af subjektive og objektive kognitive bivirkninger ved elektrokonvulsiv terapi og deres relation til depressive symptomer, stress og antagelser (LECT)

Projekt: Typer af projekterProjekt

Vis graf over relationer
Longitudinal investigation of subjective and objective cognitive side effects of electroconvulsive therapy and their relation to mood symptoms, stress and preconceptions of ECT (2016–Present): Electroconvulsive therapy (ECT) for depression is often associated with troublesome cognitive side effects, which fuel patients’ fear of ECT. However, the nature and persistence of these cognitive side effects are still unclear. There is a well-documented discrepancy between subjective (self-reported) and objective (neuropsychological) measures of cognition. The LECT study therefore examines subjective and objective measures of cognition longitudinally in depressed patients undergoing ECT and which baseline characteristics predict potential discrepancy between subjective and objective cognitive side-effects. The study is expected to be complete in September/October 2020.
Observational study involving 3 neuropsychological assessments and mood ratings before ECT, 5-7 days after ECT completion and at a 3-months follow-up assessment.
On each assessment, patients were evaluated for depressive symptoms, completed the Screen for Cognitive Impairment in Psychiatry (SCIP) and Trail Making Test-Part B (TMT-B) and rated their cognitive difficulties. Patients also rated their fear of various aspects of ECT on a visual analogue scale.
Resultater (forventede):
Patients feared the cognitive side-effects and lack of treatment efficacy more than other aspects of this treatment. The SCIP and TMT-B revealed a transient decline in objective cognition after ECT, which was reversed after three months. Patients presented with more subjective than objective cognitive difficulties at baseline and more subjective than objective cognitive side-effects of ECT. Younger age and poorer objective cognition at baseline were associated with change towards more subjective than objective cognitive side-effects immediately post-ECT. The SCIP and TMT-B are sensitive to cognitive side-effects of ECT. Patients show more subjective than objective cognitive side-effects of ECT.
Diskussion/Impact (forventet):
These insights can be used clinically to inform patients’ treatment choice and expected cognitive consequences of treatment.
The resulting paper is currently “in review”


  • Sundhedsvidenskab - Mood Disorders, Psychological assessment and psychometrics, Cognition, Observational study

ID: 61746337